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Polarity of the First Episode and Time to Diagnosis of Bipolar I Disorder

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dc.contributor.authorCha, Boseok-
dc.contributor.authorKim, Jeong Hyun-
dc.contributor.authorHa, Tae Hyon-
dc.contributor.authorChang, Jae Seung-
dc.contributor.authorHa, Kyooseob-
dc.date.accessioned2012-07-05T02:30:53Z-
dc.date.available2012-07-05T02:30:53Z-
dc.date.issued2009-06-
dc.identifier.citationPSYCHIATRY INVESTIGATION; Vol.6(2); 96-101ko_KR
dc.identifier.issn1738-3684-
dc.identifier.urihttps://hdl.handle.net/10371/78566-
dc.description.abstractObjective The current study explored the relationship between the polarity of the first episode and the timing of eventual diagnosis of bipolar I disorder, and associated clinical implications. Methods Twelve years of clinical data from the medical records of 258 inpatients meeting DSM-III-R or DSM-IV criteria for bipolar I disorder were analyzed. Subjects were divided into two groups according to the polarity of the first episode: those with depressive polarity (FE-D), and those with manic polarity (FE-M). Comparisons were made between the two groups on variables associated with the timing of diagnosis and related outcomes. Results In Population with bipolar I disorder, a significant longer time lapse from the first major mood episode to the confirmed diagnosis was associated with the FE-D group compared to the FE-M group [5.6 (+/- 6.1) vs. 2.5 (+/- 5.5) years, p<0.001]. FE-D subjects tended to have prior diagnoses of schizophrenia and major depressive disorder while FE-M subjects tended to have prior diagnoses of bipolar disorder and schizophrenia. A significantly higher rate of suicide attempts was associated with the FE-D group compared to the FE-M group (12.7 vs. 1.7%, p<0.001). Conclusion The results of this study indicate that first-episode depressive polarity is likely to be followed by a considerable delay until an eventual confirmed diagnosis of bipolar I disorder. Given that first-episode depressive patients are particularly vulnerable to unfavorable clinical Outcomes Such as suicide attempts, a more systematic approach is needed to differentiate bipolar disorder among depressed patients in their early stages.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN NEUROPSYCHIATRIC ASSOCko_KR
dc.subjectBipolar disorderko_KR
dc.subjectSuicideko_KR
dc.subjectDiagnosisko_KR
dc.subjectPolarityko_KR
dc.subjectFirst episodeko_KR
dc.titlePolarity of the First Episode and Time to Diagnosis of Bipolar I Disorderko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor차보석-
dc.contributor.AlternativeAuthor김정현-
dc.contributor.AlternativeAuthor하태현-
dc.contributor.AlternativeAuthor장재승-
dc.contributor.AlternativeAuthor하규섭-
dc.identifier.doi10.4306/pi.2009.6.2.96-
dc.citation.journaltitlePSYCHIATRY INVESTIGATION-
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