Publications
Detailed Information
Genetic Profiling in Human Adipose Tissue-Derived Mesenchymal Stromal Cells from the Idiopathic and Familial Parkin-Deficient Patients of Parkinson`s Disease in Comparison with non-PD patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Hyo-Eun | - |
dc.contributor.author | Park, Hyung Woo | - |
dc.contributor.author | Shin, Hye Young | - |
dc.contributor.author | Paek, Seung Leal | - |
dc.contributor.author | Son, Jin H. | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.date.accessioned | 2012-07-05T04:52:52Z | - |
dc.date.available | 2012-07-05T04:52:52Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE; Vol.7(2); 237-247 | ko_KR |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78591 | - |
dc.description.abstract | Purpose: With an approach of carrying out a transcriptome microarray analysis using early-passage adipose tissue-derived mesenchymal stromal cells from human adult patients with early-onset hereditary parkin deficient Parkinson`s disease (PD) as well as late-onset idiopathic PD, we aimed to understand brain pathology in PD patients. Methods: Here, we isolated human adipose tissue-derived mesenchymal stromal cells (hAD-MSCs) of patients with idiopathic PD and parkin deficient PD in comparison with non-PD patients and profiled their gene expression using Affymetrix cDNA microarray analysis. Human adipose tissue is a rich source of MSCs, providing an abundant and accessible source of adult stem cells. Results: The hAD-MSCs of patients with idiopathic PD were named as "PD", with parkin deficient PD as "Parkin" and with pituitary adenoma as "non-PD" shortly. Initially, Differentially Expressed Genes (DEGs, total 413 genes) were classified and summarized among non-PD, PD and Parkin. Moreover, using K-mean clustering analysis, we grouped DEGs into 7 clusters and gene names and genebank accession numbers between 2 and 6 were arranged. Additionally, the functional groups of human biomarker candidates were organized and compared between non-PD vs. PD and non-PD vs. Parkin. Finally, PD-related differentially regulated genes by oxidative stress were categorized among non-PD, PD and Parkin. Conclusions: This study showed that knowledge of selective gene expression profile derived from PD patients might potentially lead to better understanding of PD pathology and development of early diagnosis and effective therapy targeted their human biomarkers. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | ko_KR |
dc.subject | parkinson`s disease | ko_KR |
dc.subject | cDNA microarray human adipose tissue-derived mesenchymal stromal cells | ko_KR |
dc.subject | biomarker diagnosis | ko_KR |
dc.title | Genetic Profiling in Human Adipose Tissue-Derived Mesenchymal Stromal Cells from the Idiopathic and Familial Parkin-Deficient Patients of Parkinson`s Disease in Comparison with non-PD patients | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 문효은 | - |
dc.contributor.AlternativeAuthor | 박형우 | - |
dc.contributor.AlternativeAuthor | 신혜영 | - |
dc.contributor.AlternativeAuthor | 백승렬 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.citation.journaltitle | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.description.citedreference | Glavan G, 2009, ANAT REC, V292, P1849, DOI 10.1002/ar.21026 | - |
dc.description.citedreference | Lindgren HS, 2009, NEUROPSYCHOPHARMACOL, V34, P2477, DOI 10.1038/npp.2009.74 | - |
dc.description.citedreference | Henchcliffe C, 2008, NAT CLIN PRACT NEURO, V4, P600, DOI 10.1038/ncpneuro0924 | - |
dc.description.citedreference | Hoepken HH, 2008, EXP NEUROL, V212, P307, DOI 10.1016/j.expneurol.2008.04.004 | - |
dc.description.citedreference | Moore DJ, 2008, J NEUROCHEM, V105, P1806, DOI 10.1111/j.1471-4159.2008.05261.x | - |
dc.description.citedreference | Infante J, 2008, EUR J NEUROL, V15, P431, DOI 10.1111/j.1468-1331.2008.02092.x | - |
dc.description.citedreference | Wada-Isoe K, 2008, J NEUROL SCI, V266, P20, DOI 10.1016/j.jns.2007.08.018 | - |
dc.description.citedreference | MCCOY MK, 2008, J NEUROINFLAMM, V17, P45 | - |
dc.description.citedreference | Goris A, 2007, J NEUROL, V254, P846, DOI 10.1007/s00415-006-0414-6 | - |
dc.description.citedreference | Di Fonzo A, 2007, NEUROLOGY, V68, P1557 | - |
dc.description.citedreference | Morales I, 2007, AM J PHYSIOL-CELL PH, V292, pC1934, DOI 10.1152/ajpcell.00593.2006 | - |
dc.description.citedreference | Dominici M, 2006, CYTOTHERAPY, V8, P315, DOI 10.1080/14653240600855905 | - |
dc.description.citedreference | Abou-Sleiman PM, 2006, NAT REV NEUROSCI, V7, P207, DOI 10.1038/nrn1868 | - |
dc.description.citedreference | Grunblatt E, 2004, J NEURAL TRANSM, V111, P1543, DOI 10.1007/s00702-004-0212-1 | - |
dc.description.citedreference | Yoo MS, 2004, NEUROCHEM RES, V29, P1223 | - |
dc.description.citedreference | Muftuoglu M, 2004, MOVEMENT DISORD, V19, P544, DOI 10.1002/mds.10695 | - |
dc.description.citedreference | Palacino JJ, 2004, J BIOL CHEM, V279, P18614, DOI 10.1074/jbc.M401135200 | - |
dc.description.citedreference | Henry B, 2003, EXP NEUROL, V183, P458, DOI 10.1016/S0014-4886(03)00064-5 | - |
dc.description.citedreference | Zuk PA, 2002, MOL BIOL CELL, V13, P4279, DOI 10.1091/mbc.E02-02-0105 | - |
dc.description.citedreference | Farkas LM, 2002, J NEURAL TRANSM, V109, P267 | - |
dc.description.citedreference | Levite M, 2001, EUR J IMMUNOL, V31, P3504 | - |
dc.description.citedreference | Picklo MJ, 2001, BRAIN RES, V916, P229 | - |
dc.description.citedreference | Soukas A, 2000, GENE DEV, V14, P963 | - |
dc.description.citedreference | Pittenger MF, 1999, SCIENCE, V284, P143 | - |
dc.description.citedreference | Bruder SP, 1998, CLIN ORTHOP RELAT R, pS247 | - |
dc.description.citedreference | DEWITT DA, 1994, BRAIN RES, V656, P205 | - |
dc.description.tc | 0 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.