Browse

Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder

DC Field Value Language
dc.contributor.authorJang, Joon Hwan-
dc.contributor.authorKim, Jae-Hun-
dc.contributor.authorJung, Wi Hoon-
dc.contributor.authorChoi, Jung-Seok-
dc.contributor.authorLee, Jong-Min-
dc.contributor.authorKang, Do-Hyung-
dc.contributor.authorKwon, Jun Soo-
dc.contributor.authorChoi, Chi-Hoon-
dc.contributor.authorJung, Myung Hun-
dc.date.accessioned2012-07-05T05:51:52Z-
dc.date.available2012-07-05T05:51:52Z-
dc.date.issued2010-05-03-
dc.identifier.citationNEUROSCIENCE LETTERS; Vol.474(3); 158-162ko_KR
dc.identifier.issn0304-3940-
dc.identifier.urihttp://hdl.handle.net/10371/78594-
dc.description.abstractObsessions and compulsions mediated by cognitive inflexibility might be associated with abnormal resting state functional connectivity in the default mode network (DMN) that represents intrinsically generated neuronal activity. It was hypothesized that decreased functional connectivity in the DMN would occur in components of fronto-subcortical circuits in patients with obsessive-compulsive disorder (OCD). Twenty-two unmedicated OCD patients and 22 age- and sex-matched healthy controls received resting state functional scanning runs. The posterior cingulate cortex (PCC) region was chosen as the seed region for the connectivity analysis. Correlations between temporal connectivity with the seed region and scores on clinical measures and obsessive-compulsive symptom dimensions were also assessed. OCD patients demonstrated less functional connectivity within the DMN in the anterior cingulate cortex, middle frontal gyrus, and putamen compared to controls. The functional connectivity to the PCC seed region in OCD patients was in the direction opposite to that in the prefrontal areas with regard to scores on cleaning and obsessions/checking dimensions of OCD. These data provide evidence for fronto-subcortical dysfunction in OCD. Results from this study also support the notion that OCD is a heterogeneous disorder mediated by distinct circuits.ko_KR
dc.description.sponsorshipThis work was supported by the Korea Research Foundation
Grant funded by the Korean Government (KRF-2008-313-E00341).
ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectObsessive-compulsive disorderko_KR
dc.subjectFunctional connectivityko_KR
dc.subjectResting stateko_KR
dc.subjectDefault mode networkko_KR
dc.titleFunctional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorderko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor장준환-
dc.contributor.AlternativeAuthor김재훈-
dc.contributor.AlternativeAuthor정이훈-
dc.contributor.AlternativeAuthor최정석-
dc.contributor.AlternativeAuthor정명훈-
dc.contributor.AlternativeAuthor이종민-
dc.contributor.AlternativeAuthor최치훈-
dc.contributor.AlternativeAuthor강도형-
dc.contributor.AlternativeAuthor권준수-
dc.identifier.doi10.1016/j.neulet.2010.03.031-
dc.citation.journaltitleNEUROSCIENCE LETTERS-
dc.description.citedreferenceHarrison BJ, 2009, ARCH GEN PSYCHIAT, V66, P1189-
dc.description.citedreferenceHa TH, 2009, NEUROREPORT, V20, P735, DOI 10.1097/WNR.0b013e32832ad3da-
dc.description.citedreferencevan den Heuvel OA, 2009, BRAIN, V132, P853, DOI 10.1093/brain/awn267-
dc.description.citedreferenceBloch MH, 2008, AM J PSYCHIAT, V165, P1532-
dc.description.citedreferenceRotge JY, 2008, J PSYCHIATR NEUROSCI, V33, P405-
dc.description.citedreferenceChamberlain SR, 2008, SCIENCE, V321, P421, DOI 10.1126/science.1154433-
dc.description.citedreferenceBuckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011-
dc.description.citedreferenceMenzies L, 2008, NEUROSCI BIOBEHAV R, V32, P525, DOI 10.1016/j.neubiorev.2007.09.005-
dc.description.citedreferenceGu BM, 2008, BRAIN, V131, P155, DOI 10.1093/brain/awm277-
dc.description.citedreferenceFox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201-
dc.description.citedreferenceGreicius MD, 2007, BIOL PSYCHIAT, V62, P429, DOI 10.1016/j.biopsych.2006.09.020-
dc.description.citedreferenceYucel M, 2007, ARCH GEN PSYCHIAT, V64, P946-
dc.description.citedreferenceGarrity AG, 2007, AM J PSYCHIAT, V164, P450-
dc.description.citedreferenceMason MF, 2007, SCIENCE, V315, P393, DOI 10.1126/science.1131295-
dc.description.citedreferenceBirn RM, 2006, NEUROIMAGE, V31, P1536, DOI 10.1016/j.neuroimage.2006.02.048-
dc.description.citedreferenceJang JH, 2006, AM J PSYCHIAT, V163, P1202-
dc.description.citedreferenceFransson P, 2006, NEUROPSYCHOLOGIA, V44, P2836, DOI 10.1016/j.neuropsychologia.2006.06.017-
dc.description.citedreferenceFransson P, 2005, HUM BRAIN MAPP, V26, P15, DOI 10.1002/hbm.20113-
dc.description.citedreferenceFox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102-
dc.description.citedreferenceChamberlain SR, 2005, NEUROSCI BIOBEHAV R, V29, P399, DOI 10.1016/j.neubiorev.2004.11.006-
dc.description.citedreferencevan den Heuvel OA, 2005, ARCH GEN PSYCHIAT, V62, P301-
dc.description.citedreferencevan der Wee NJ, 2004, AM J PSYCHIAT, V161, P2201-
dc.description.citedreferenceMataix-Cols D, 2004, ARCH GEN PSYCHIAT, V61, P564-
dc.description.citedreferenceMacey PM, 2004, NEUROIMAGE, V22, P360, DOI 10.1016/j.neuroimage.2003.12.042-
dc.description.citedreferenceMataix-Cols D, 2002, AM J PSYCHIAT, V159, P263-
dc.description.citedreferenceTzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978-
dc.description.citedreferenceGusnard DA, 2001, P NATL ACAD SCI USA, V98, P4259-
dc.description.citedreferenceRaichle ME, 2001, P NATL ACAD SCI USA, V98, P676-
dc.description.citedreferenceSAXENA S, 1998, BRIT J PSYCHIAT S, V35, P26-
dc.description.citedreferenceFIRST MB, 1996, STRUCTURED CLIN INTE-
dc.description.citedreferenceDEVINSKY O, 1995, BRAIN, V118, P279-
dc.description.citedreferenceBECK AT, 1990, MANUAL BECK ANXIETY-
dc.description.citedreferenceGOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006-
dc.description.citedreferenceBECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561-
dc.description.tc6-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse