Publications
Detailed Information
Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Joon Hwan | - |
dc.contributor.author | Kim, Jae-Hun | - |
dc.contributor.author | Jung, Wi Hoon | - |
dc.contributor.author | Choi, Jung-Seok | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Kang, Do-Hyung | - |
dc.contributor.author | Kwon, Jun Soo | - |
dc.contributor.author | Choi, Chi-Hoon | - |
dc.contributor.author | Jung, Myung Hun | - |
dc.date.accessioned | 2012-07-05T05:51:52Z | - |
dc.date.available | 2012-07-05T05:51:52Z | - |
dc.date.issued | 2010-05-03 | - |
dc.identifier.citation | NEUROSCIENCE LETTERS; Vol.474(3); 158-162 | ko_KR |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78594 | - |
dc.description.abstract | Obsessions and compulsions mediated by cognitive inflexibility might be associated with abnormal resting state functional connectivity in the default mode network (DMN) that represents intrinsically generated neuronal activity. It was hypothesized that decreased functional connectivity in the DMN would occur in components of fronto-subcortical circuits in patients with obsessive-compulsive disorder (OCD). Twenty-two unmedicated OCD patients and 22 age- and sex-matched healthy controls received resting state functional scanning runs. The posterior cingulate cortex (PCC) region was chosen as the seed region for the connectivity analysis. Correlations between temporal connectivity with the seed region and scores on clinical measures and obsessive-compulsive symptom dimensions were also assessed. OCD patients demonstrated less functional connectivity within the DMN in the anterior cingulate cortex, middle frontal gyrus, and putamen compared to controls. The functional connectivity to the PCC seed region in OCD patients was in the direction opposite to that in the prefrontal areas with regard to scores on cleaning and obsessions/checking dimensions of OCD. These data provide evidence for fronto-subcortical dysfunction in OCD. Results from this study also support the notion that OCD is a heterogeneous disorder mediated by distinct circuits. | ko_KR |
dc.description.sponsorship | This work was supported by the Korea Research Foundation
Grant funded by the Korean Government (KRF-2008-313-E00341). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER IRELAND LTD | ko_KR |
dc.subject | Obsessive-compulsive disorder | ko_KR |
dc.subject | Functional connectivity | ko_KR |
dc.subject | Resting state | ko_KR |
dc.subject | Default mode network | ko_KR |
dc.title | Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 장준환 | - |
dc.contributor.AlternativeAuthor | 김재훈 | - |
dc.contributor.AlternativeAuthor | 정이훈 | - |
dc.contributor.AlternativeAuthor | 최정석 | - |
dc.contributor.AlternativeAuthor | 정명훈 | - |
dc.contributor.AlternativeAuthor | 이종민 | - |
dc.contributor.AlternativeAuthor | 최치훈 | - |
dc.contributor.AlternativeAuthor | 강도형 | - |
dc.contributor.AlternativeAuthor | 권준수 | - |
dc.identifier.doi | 10.1016/j.neulet.2010.03.031 | - |
dc.citation.journaltitle | NEUROSCIENCE LETTERS | - |
dc.description.citedreference | Harrison BJ, 2009, ARCH GEN PSYCHIAT, V66, P1189 | - |
dc.description.citedreference | Ha TH, 2009, NEUROREPORT, V20, P735, DOI 10.1097/WNR.0b013e32832ad3da | - |
dc.description.citedreference | van den Heuvel OA, 2009, BRAIN, V132, P853, DOI 10.1093/brain/awn267 | - |
dc.description.citedreference | Bloch MH, 2008, AM J PSYCHIAT, V165, P1532 | - |
dc.description.citedreference | Rotge JY, 2008, J PSYCHIATR NEUROSCI, V33, P405 | - |
dc.description.citedreference | Chamberlain SR, 2008, SCIENCE, V321, P421, DOI 10.1126/science.1154433 | - |
dc.description.citedreference | Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011 | - |
dc.description.citedreference | Menzies L, 2008, NEUROSCI BIOBEHAV R, V32, P525, DOI 10.1016/j.neubiorev.2007.09.005 | - |
dc.description.citedreference | Gu BM, 2008, BRAIN, V131, P155, DOI 10.1093/brain/awm277 | - |
dc.description.citedreference | Fox MD, 2007, NAT REV NEUROSCI, V8, P700, DOI 10.1038/nrn2201 | - |
dc.description.citedreference | Greicius MD, 2007, BIOL PSYCHIAT, V62, P429, DOI 10.1016/j.biopsych.2006.09.020 | - |
dc.description.citedreference | Yucel M, 2007, ARCH GEN PSYCHIAT, V64, P946 | - |
dc.description.citedreference | Garrity AG, 2007, AM J PSYCHIAT, V164, P450 | - |
dc.description.citedreference | Mason MF, 2007, SCIENCE, V315, P393, DOI 10.1126/science.1131295 | - |
dc.description.citedreference | Birn RM, 2006, NEUROIMAGE, V31, P1536, DOI 10.1016/j.neuroimage.2006.02.048 | - |
dc.description.citedreference | Jang JH, 2006, AM J PSYCHIAT, V163, P1202 | - |
dc.description.citedreference | Fransson P, 2006, NEUROPSYCHOLOGIA, V44, P2836, DOI 10.1016/j.neuropsychologia.2006.06.017 | - |
dc.description.citedreference | Fransson P, 2005, HUM BRAIN MAPP, V26, P15, DOI 10.1002/hbm.20113 | - |
dc.description.citedreference | Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102 | - |
dc.description.citedreference | Chamberlain SR, 2005, NEUROSCI BIOBEHAV R, V29, P399, DOI 10.1016/j.neubiorev.2004.11.006 | - |
dc.description.citedreference | van den Heuvel OA, 2005, ARCH GEN PSYCHIAT, V62, P301 | - |
dc.description.citedreference | van der Wee NJ, 2004, AM J PSYCHIAT, V161, P2201 | - |
dc.description.citedreference | Mataix-Cols D, 2004, ARCH GEN PSYCHIAT, V61, P564 | - |
dc.description.citedreference | Macey PM, 2004, NEUROIMAGE, V22, P360, DOI 10.1016/j.neuroimage.2003.12.042 | - |
dc.description.citedreference | Mataix-Cols D, 2002, AM J PSYCHIAT, V159, P263 | - |
dc.description.citedreference | Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978 | - |
dc.description.citedreference | Gusnard DA, 2001, P NATL ACAD SCI USA, V98, P4259 | - |
dc.description.citedreference | Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676 | - |
dc.description.citedreference | SAXENA S, 1998, BRIT J PSYCHIAT S, V35, P26 | - |
dc.description.citedreference | FIRST MB, 1996, STRUCTURED CLIN INTE | - |
dc.description.citedreference | DEVINSKY O, 1995, BRAIN, V118, P279 | - |
dc.description.citedreference | BECK AT, 1990, MANUAL BECK ANXIETY | - |
dc.description.citedreference | GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006 | - |
dc.description.citedreference | BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561 | - |
dc.description.tc | 6 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.