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Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Cho, Yu Jin | - |
dc.contributor.author | Kim, Ji Hun | - |
dc.contributor.author | Yoon, Jiyeon | - |
dc.contributor.author | Cho, Sung Jin | - |
dc.contributor.author | Park, Jong-Wan | - |
dc.contributor.author | Lee, Hee Eun | - |
dc.contributor.author | Lee, Byung Lan | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Ko, Young San | - |
dc.date.accessioned | 2012-07-09T08:04:02Z | - |
dc.date.available | 2012-07-09T08:04:02Z | - |
dc.date.issued | 2010-08-12 | - |
dc.identifier.citation | BMC GASTROENTEROLOGY; Vol.10; 91 | ko_KR |
dc.identifier.issn | 1471-230X | - |
dc.identifier.uri | https://hdl.handle.net/10371/78663 | - |
dc.description.abstract | Background: Aberrant regulation of glycogen synthase kinase-3 beta (GSK-3 beta) has been implicated in several human cancers; however, it has not been reported in the gastric cancer tissues to date. The present study was performed to determine the expression status of active form of GSK-3 beta phosphorylated at Tyr(216) (pGSK-3 beta) and its relationship with other tumor-associated proteins in human gastric cancers. Methods: Immunohistochemistry was performed on tissue array slides containing 281 human gastric carcinoma specimens. In addition, gastric cancer cells were cultured and treated with a GSK-3 beta inhibitor lithium chloride (LiCl) for immunoblot analysis. Results: We found that pGSK-3 beta was expressed in 129 (46%) of 281 cases examined, and was higher in the early-stages of pathologic tumor-node-metastasis (P < 0.001). The expression of pGSK-3 beta inversely correlated with lymphatic invasion (P < 0.001) and lymph node metastasis (P < 0.001) and correlated with a longer patient survival (P < 0.001). In addition, pGSK-3 beta expression positively correlated with that of p16, p21, p27, p53, APC, PTEN, MGMT, SMAD4, or KAl1 (P < 0.05), but not with that of cyclin D1. This was confirmed by immunoblot analysis using SNU-668 gastric cancer cells treated with LiCl. Conclusions: GSK-3 beta activation was frequently observed in early-stage gastric carcinoma and was significantly correlated with better prognosis. Thus, these findings suggest that GSK-3 beta activation is a useful prognostic marker for the early-stage gastric cancer. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BIOMED CENTRAL LTD | ko_KR |
dc.title | Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조유진 | - |
dc.contributor.AlternativeAuthor | 김지훈 | - |
dc.contributor.AlternativeAuthor | 윤지연 | - |
dc.contributor.AlternativeAuthor | 조성진 | - |
dc.contributor.AlternativeAuthor | 고영산 | - |
dc.contributor.AlternativeAuthor | 박종완 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 이희은 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 이병란 | - |
dc.identifier.doi | 10.1186/1471-230X-10-91 | - |
dc.citation.journaltitle | BMC GASTROENTEROLOGY | - |
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