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Expression of l-Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase (Phgdh) and Neutral Amino Acid Transporter ASCT1 Following an Excitotoxic Lesion in the Mouse Hippocampus

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dc.contributor.authorJeon, Gye Sun-
dc.contributor.authorChoi, Deok Hyung-
dc.contributor.authorLee, Ha Na-
dc.contributor.authorKim, Dong Woon-
dc.contributor.authorCho, Sa Sun-
dc.contributor.authorChung, Chun Kee-
dc.date.accessioned2012-07-09T08:18:05Z-
dc.date.available2012-07-09T08:18:05Z-
dc.date.issued2009-05-
dc.identifier.citationNEUROCHEMICAL RESEARCH; Vol.34, No.5; 827-834ko_KR
dc.identifier.issn0364-3190-
dc.identifier.urihttps://hdl.handle.net/10371/78665-
dc.description.abstractThe nonessential amino acid l-serine functions as a glia-derived trophic factor and strongly promotes the survival and differentiation of cultured neurons. The l-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (Phgdh) and the small neutral amino acid transporter ASCT1 are preferentially expressed in specific glial cells in the brain. However, their roles in pathological progression remain unclear. We examined the expression of Phgdh and ASCT1 in kainic acid (KA)-induced neurodegeneration of the mouse hippocampus using immunohistochemistry and Western blots. Our quantitative analysis revealed that Phgdh and ASCT1 were constitutively expressed in the normal brain and transiently upregulated by KA-treatment. At the cellular level, Phgdh was expressed in astrocytes in control and in KA-treated mice while ASCT1 that was expressed primarily in the neurons of the normal brain appeared also in activated astrocytes in KA treated mouse brain. The preferential glial expression of ASCT1 was consistent with that of Phgdh. These results demonstrate injury-induced changes in Phgdh and ASCT1 expression. It is hypothesized that the secretion of l-serine is regulated by astrocytes in response to toxic molecules such as glutamate and free radicals that promote neurodegeneration, and may correspond to the level of l-serine needed for neuronal survival and glial activation during brain insults.ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGER/PLENUM PUBLISHERSko_KR
dc.subjectPhgdhko_KR
dc.subjectL-Serineko_KR
dc.subjectImmunohistochemistryko_KR
dc.subjectAstrocyteko_KR
dc.subjectASCT1ko_KR
dc.subjectKainic acidko_KR
dc.titleExpression of l-Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase (Phgdh) and Neutral Amino Acid Transporter ASCT1 Following an Excitotoxic Lesion in the Mouse Hippocampusko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor전계선-
dc.contributor.AlternativeAuthor최덕형-
dc.contributor.AlternativeAuthor이하나-
dc.contributor.AlternativeAuthor김동운-
dc.contributor.AlternativeAuthor정춘기-
dc.contributor.AlternativeAuthor조사순-
dc.identifier.doi10.1007/s11064-008-9831-5-
dc.citation.journaltitleNEUROCHEMICAL RESEARCH-
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