Publications
Detailed Information
Expression of l-Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase (Phgdh) and Neutral Amino Acid Transporter ASCT1 Following an Excitotoxic Lesion in the Mouse Hippocampus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Gye Sun | - |
dc.contributor.author | Choi, Deok Hyung | - |
dc.contributor.author | Lee, Ha Na | - |
dc.contributor.author | Kim, Dong Woon | - |
dc.contributor.author | Cho, Sa Sun | - |
dc.contributor.author | Chung, Chun Kee | - |
dc.date.accessioned | 2012-07-09T08:18:05Z | - |
dc.date.available | 2012-07-09T08:18:05Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | NEUROCHEMICAL RESEARCH; Vol.34, No.5; 827-834 | ko_KR |
dc.identifier.issn | 0364-3190 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78665 | - |
dc.description.abstract | The nonessential amino acid l-serine functions as a glia-derived trophic factor and strongly promotes the survival and differentiation of cultured neurons. The l-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (Phgdh) and the small neutral amino acid transporter ASCT1 are preferentially expressed in specific glial cells in the brain. However, their roles in pathological progression remain unclear. We examined the expression of Phgdh and ASCT1 in kainic acid (KA)-induced neurodegeneration of the mouse hippocampus using immunohistochemistry and Western blots. Our quantitative analysis revealed that Phgdh and ASCT1 were constitutively expressed in the normal brain and transiently upregulated by KA-treatment. At the cellular level, Phgdh was expressed in astrocytes in control and in KA-treated mice while ASCT1 that was expressed primarily in the neurons of the normal brain appeared also in activated astrocytes in KA treated mouse brain. The preferential glial expression of ASCT1 was consistent with that of Phgdh. These results demonstrate injury-induced changes in Phgdh and ASCT1 expression. It is hypothesized that the secretion of l-serine is regulated by astrocytes in response to toxic molecules such as glutamate and free radicals that promote neurodegeneration, and may correspond to the level of l-serine needed for neuronal survival and glial activation during brain insults. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | ko_KR |
dc.subject | Phgdh | ko_KR |
dc.subject | L-Serine | ko_KR |
dc.subject | Immunohistochemistry | ko_KR |
dc.subject | Astrocyte | ko_KR |
dc.subject | ASCT1 | ko_KR |
dc.subject | Kainic acid | ko_KR |
dc.title | Expression of l-Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase (Phgdh) and Neutral Amino Acid Transporter ASCT1 Following an Excitotoxic Lesion in the Mouse Hippocampus | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 전계선 | - |
dc.contributor.AlternativeAuthor | 최덕형 | - |
dc.contributor.AlternativeAuthor | 이하나 | - |
dc.contributor.AlternativeAuthor | 김동운 | - |
dc.contributor.AlternativeAuthor | 정춘기 | - |
dc.contributor.AlternativeAuthor | 조사순 | - |
dc.identifier.doi | 10.1007/s11064-008-9831-5 | - |
dc.citation.journaltitle | NEUROCHEMICAL RESEARCH | - |
dc.description.citedreference | Jeon GS, 2008, NEUROCHEM RES, V33, P179, DOI 10.1007/s11064-007-9434-6 | - |
dc.description.citedreference | Yamagata K, 2006, NEUROSCIENCE, V143, P729, DOI 10.1016/j.neuroscience.2006.08.050 | - |
dc.description.citedreference | Jeon GS, 2006, NEUROCHEM RES, V31, P1371, DOI 10.1007/s11064-006-9184-x | - |
dc.description.citedreference | Parathath SR, 2006, J CELL SCI, V119, P339, DOI 10.1242/jcs.02734 | - |
dc.description.citedreference | Jeon GS, 2004, GLIA, V48, P250, DOI 10.1002/glia.20075 | - |
dc.description.citedreference | Hashimoto Y, 2004, JPN J VET RES, V52, P113 | - |
dc.description.citedreference | Yamamoto T, 2004, NEUROSCI RES, V49, P101, DOI 10.1016/j.neures.2004.02.004 | - |
dc.description.citedreference | Yoshida K, 2004, J BIOL CHEM, V279, P3573, DOI 10.1074/jbc.C300507200 | - |
dc.description.citedreference | Yamashita N, 2003, ARCH HISTOL CYTOL, V66, P429 | - |
dc.description.citedreference | Furuya S, 2003, ARCH HISTOL CYTOL, V66, P109 | - |
dc.description.citedreference | Chen YM, 2003, J CEREBR BLOOD F MET, V23, P137, DOI 10.1097/01.WCB.0000044631.80210.3C | - |
dc.description.citedreference | Sakai K, 2003, J NEUROSCI, V23, P550 | - |
dc.description.citedreference | Armano S, 2002, J BIOL CHEM, V277, P10467, DOI 10.1074/jbc.M110942200 | - |
dc.description.citedreference | De Koning TJ, 2002, J INHERIT METAB DIS, V25, P119, DOI 10.1023/A:1015624726822 | - |
dc.description.citedreference | Chaudhry FA, 2002, J NEUROSCI, V22, P62 | - |
dc.description.citedreference | Weiss MD, 2001, DEV BRAIN RES, V130, P183 | - |
dc.description.citedreference | Yamasaki M, 2001, J NEUROSCI, V21, P7691 | - |
dc.description.citedreference | Sugishita H, 2001, J NEUROSCI RES, V64, P392 | - |
dc.description.citedreference | Klomp LWJ, 2000, AM J HUM GENET, V67, P1389 | - |
dc.description.citedreference | Furuya S, 2000, P NATL ACAD SCI USA, V97, P11528 | - |
dc.description.citedreference | Reimer RJ, 2000, P NATL ACAD SCI USA, V97, P7715 | - |
dc.description.citedreference | Varoqui H, 2000, J BIOL CHEM, V275, P4049 | - |
dc.description.citedreference | Zhang L, 1999, EXP BRAIN RES, V126, P509 | - |
dc.description.citedreference | de Koning TJ, 1998, ANN NEUROL, V44, P261 | - |
dc.description.citedreference | Mitoma J, 1998, NEUROSCI RES, V30, P195 | - |
dc.description.citedreference | Zerangue N, 1996, J BIOL CHEM, V271, P27991 | - |
dc.description.citedreference | Jaeken J, 1996, ARCH DIS CHILD, V74, P542 | - |
dc.description.citedreference | SAVOCA R, 1995, J NEUROSCI METH, V61, P159 | - |
dc.description.citedreference | SPERK G, 1994, PROG NEUROBIOL, V42, P1 | - |
dc.description.citedreference | ARRIZA JL, 1993, J BIOL CHEM, V268, P15329 | - |
dc.description.citedreference | SHAFQAT S, 1993, J BIOL CHEM, V268, P15351 | - |
dc.description.citedreference | MITCHELL J, 1993, EXP NEUROL, V121, P224 | - |
dc.description.citedreference | BEAL MF, 1992, FASEB J, V6, P3338 | - |
dc.description.citedreference | LAURSEN SE, 1986, J PHARMACOL METHOD, V16, P355 | - |
dc.description.citedreference | ROTHMAN SM, 1986, ANN NEUROL, V19, P105 | - |
dc.description.citedreference | NADLER JV, 1980, J COMP NEUROL, V192, P333 | - |
dc.description.tc | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.