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Epigenetic Regulation of Cancer-Associated Genes in Ovarian Cancer

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dc.contributor.authorShin, Young Kee-
dc.contributor.authorKwon, Mi Jeong-
dc.identifier.citationInternational Journal of Molecular Sciences; Vol.12(2); pp. 983-1008ko_KR
dc.description.abstractThe involvement of epigenetic aberrations in the development and progression of tumors is now well established. However, most studies have focused on the epigenetic inactivation of tumor suppressor genes during tumorigenesis and little is known about the epigenetic activation of cancer-associated genes, except for the DNA hypomethylation of some genes. Recently, we reported that the overexpression of cancer-promoting genes in ovarian cancer is associated with the loss of repressive histone modifications. This discovery suggested that epigenetic derepression may contribute to ovarian tumorigenesis by constituting a possible mechanism for the overexpression of oncogenes or cancer-promoting genes in tumors. The emerging importance of epigenetic aberrations in tumor initiation and in the regulation of cancer-initiating cells, suggests that epigenetically regulated genes may be promising therapeutic targets and biomarkers. Given that the current challenges in ovarian cancer include the identification of biomarkers for early cancer detection and the discovery of novel therapeutic targets for patients with recurrent malignancies undergoing chemotherapy, understanding the epigenetic changes that occur in ovarian cancer is crucial. This review looks at epigenetic mechanisms involved in the regulation of cancer-associated genes, including the contribution of epigenetic derepression to the activation of cancer-associated genes in ovarian cancer. In addition, possible epigenetic therapies targeting epigenetically dysregulated genes are discussed. A better understanding of the epigenetic changes in ovarian cancer will contribute to the improvement of patient outcomes.ko_KR
dc.subjectCancer-initiating cellsko_KR
dc.subjectDNA methylationko_KR
dc.subjectEpigenetic derepressionko_KR
dc.subjectEpigenetic therapyko_KR
dc.subjectHistone modificationko_KR
dc.subjectOvarian cancerko_KR
dc.titleEpigenetic Regulation of Cancer-Associated Genes in Ovarian Cancerko_KR
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