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Generation of dynamic temporal and spatial concentration gradients using microfluidic devices

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dc.contributor.authorLin, Francis-
dc.contributor.authorSaadi, Wajeeh-
dc.contributor.authorRhee, Seog Woo-
dc.contributor.authorWang, Shur-Jen-
dc.contributor.authorMittal, Sukant-
dc.contributor.authorJeon, Noo Li-
dc.date.accessioned2009-08-28T04:42:00Z-
dc.date.available2009-08-28T04:42:00Z-
dc.date.issued2004-06-
dc.identifier.citationLab Chip, 2004, 4, 164-167en
dc.identifier.issn1473-0197-
dc.identifier.urihttps://hdl.handle.net/10371/7977-
dc.description.abstractThis paper describes a microfluidic approach to generate dynamic temporal and spatial concentration gradients using a single microfluidic device. Compared to a previously described method that produced a single fixed gradient shape for each device, this approach combines a simple mixer module with gradient generating network to control and manipulate a number of different gradient shapes. The gradient profile is determined by the configuration of fluidic inputs as well as the design of microchannel network. By controlling the relative flow rates of the fluidic inputs using separate syringe pumps, the resulting composition of the inlets that feed the gradient generator can be dynamically controlled to generate temporal and spatial gradients. To demonstrate the concept and illustrate this approach, examples of devices that generate (1) temporal gradients of homogeneous concentrations, (2) linear gradients with dynamically controlled slope, baseline, and direction, and (3) nonlinear gradients with controlled nonlinearity are shown and their limitations are described.en
dc.description.sponsorshipNSF (Grant No. DBI-0138055)
U.S. Public Health Service-National Institutes of Health General Medical Science Grant (GM-66051
en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.subjectgradienten
dc.subjectmicrofluidic deviceen
dc.titleGeneration of dynamic temporal and spatial concentration gradients using microfluidic devicesen
dc.typeArticleen
dc.contributor.AlternativeAuthor전누리-
dc.contributor.AlternativeAuthor이석우-
dc.identifier.doi10.1039/b313600k-
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