S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 23 No.1 (1982)
급성 일산화탄소중독시 고압산소요법시행이 백서의 임신손모에 미치는 영향
The Experimental Study on the Effect of the Hyperbaric Oxygenation on the Pregnancy Wastage of the Rats in Acute Carbon Monoxide Poisoning
- 조수헌; 윤덕노
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.23 No.1, pp. 67-75
- There have been not a few clinical and experimental reports on the effect of acute carbon monoxide
poisoning upon the course and outcome of pregnancy.
Significantly high pregnancy wastage was observed
and the interruption of pregnancy was found to be
typical pattern of wastage. The hypoxic effect by
the formation of fetal carboxyhemoglobin is regarded
as main cause of the wastage.
Author designed this study to confirm the effect
of hyperbaric oxygenation on the pregnancy wastage
followed by acute carbon monoxide poisoning. Using
albino rats, experimental groups were divided into
control, acute exposure and no treatment, acute exposure
and hyperbaric oxygenation, and hyperbaric
oxygenation without exposure.
Exposed groups were exposed to the concentration
of 5,000 ppm of carbon monoxide for 20 minutes.
Following findings were observed as the experimental
1. The pregnancy wastage was prominent at the
stage corresponding to the organogenesis. As a result,
total interruption rate was the highest during the
8th to 11th embryonic day.
2. The treatment measures with the hyperbaric
oxygenation followed by acute carbon monoxide poisoning
ensued in remarkable reduction of pregancy
wastage. This finding is indicating the alleviation of
hypoxic effect of carbon monoxide poisoning by hyperbaric
oxygenation and neutralization of the adverse
effect of hypoxia in inducing pregnancy wastage.
3. Hyperbaric oxygenation per se represents no
particular hazard to the pregnancy.
4. There have been no changes in fctal body weight
among experimental groups that sustained the
pregnancy to term. Hemogram at term also showed
no significant changes. These findings make such
speculation possible that the hypoxic effect induced
by acute carbon monoxide wouldn't persist longer
since the cessation of carbon monoxide exposure.