이산화질소-아황산 혼합가스흡입이 백서 각장기의 장기-체중비, 수분함량 및 혈액상의 병화에 미치는 영향

Abstract

Nitrogen dioxide (NO,) and sulfur dioxide (SO,) are significant components of air pollutants. Their main source is the automobile exhaust. By difference of geographical variables and climatological condition, NO, plays as major component of photochemical oxidant as in Los Angeles and SO, is responsible in London type Smog Accident. In prior to these two irritant gas became serious air pollutants as the cause of hazard to human body and vegetables, main interest had been concentrated on the acute poisoning by relatively high concentration in the field of the industrial hygiene. But in urban life,many people are apt to inhale various noxious gases, even though the concentrations are still low to evoke noticeable acute poisoning. Although we had seen in air pollution accident, manifest health hazards could be observed. As the irritant gases, these two gases act on epi thelium of air way tract and provokes inflammatory responses, and also the formation of methemoglobin by nitrogen dioxide has been observed. There are many case reports on the simple exposure to these two gases, but very few reports on the combined effect of these two gases. In air pollution, many toxic gases are existing in mixed state. The additive. synergistic or antagonistic actions are expected by the type of combination. Authors designed tbis study to evaluate the effects of NO,-SO, mixed gas inhalation on the organ-body weight ratio, water contents and hemogram of rat. The rats were exposed mixed gas of 50ppm NO. and 50ppm SO, for 4 hours, following findings were observed. 1. In experimental group, organ-body weight ratioincreased in the lung and the brain significantly. Increase rate was predominant in the right middle and right lower lobe. The water contents showed same tendency. 2. The formation of methemoglobin increased in the experimental group compared to the control group and also there was significant increase in the number of reticulocyte. 3. The decrease of mean corpuscular volume was accompanied by the increase in mean corpuscular hemoglobin concentration.