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Retinoid X receptor a acts as alpha negative regulator in Nurr1-induced dopaminergic differentiation in rat neural precursor cells
DC Field | Value | Language |
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dc.contributor.author | Yoon, Eun-Hye | - |
dc.contributor.author | Lee, Kuem Ju | - |
dc.contributor.author | Kim, Yong-Seok | - |
dc.contributor.author | Chang, Mi-Sook | - |
dc.contributor.author | Park, Chang-Hwan | - |
dc.contributor.author | Lee, Sang-Hun | - |
dc.date.accessioned | 2013-01-14T05:45:41Z | - |
dc.date.available | 2013-01-14T05:45:41Z | - |
dc.date.issued | 2010-12-29 | - |
dc.identifier.citation | Neuroreport Vol.21 No.18, pp.1162-1166 | ko_KR |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.issn | 1473-558X(Online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/80361 | - |
dc.description.abstract | To investigate the role of retinoid X receptor alpha (RXR alpha)-Nurr1 heterodimers in tyrosine hydroxylase (TH) expression, we observed retrovirus-induced RXR alpha-Nurr1 heterodimer interactions with, and transactivation of, the TH promoter region in cultured rat embryonic neural precursor cells. Interestingly, forced expression of RXR alpha with Nurr1 remarkably reduced Nurr1 activity in TH + dopaminergic neuron generation and significantly down-regulated TH promoter activity. These regulatory activities were altered in both Nurr1(dim-) and RXR alpha(dim-) that disrupted dimeric binding, verifying that the Nurr1-RXR alpha heterodimer represses TH promoter activity. Therefore, a plausible explanation for the inhibitory role of RXR alpha in Nurr1-induced TH expression is that RXR alpha differentially affects an inhibitory element of the TH promoter. NeuroReport 21: 1162-1166 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | ko_KR |
dc.description.sponsorship | Grants (SC-3140) from the Stem Cell Research Center of the 21st Century Frontier Research Program, and the Future-based Technology Development Program (2010-0020232) funded by the National Research Foundation
of Korea of the Ministry of Education, Science and Technology, Republic of Korea, supported this research. | - |
dc.description.sponsorship | The authors thank Professor Chun-Hyung Kim at
McLean Hospital, Harvard Medical School for scientific advices of this work. Grants (SC-3140) from the Stem Cell Research Center of the 21st Century Frontier Research Program, and the Future-based Technology Development Program (2010-0020232) funded by the National Research Foundation of Korea of the Ministry of Education, Science and Technology, Republic of Korea, supported this research. | - |
dc.language.iso | en | ko_KR |
dc.publisher | Wolters Kluwer Health | ko_KR |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.subject | dopaminergic differentiation | ko_KR |
dc.subject | retinoid X receptor alpha | ko_KR |
dc.subject | Nurr1 | ko_KR |
dc.subject | rat embryonic neural precursor cells | ko_KR |
dc.title | Retinoid X receptor a acts as alpha negative regulator in Nurr1-induced dopaminergic differentiation in rat neural precursor cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤은혜 | - |
dc.contributor.AlternativeAuthor | 이금주 | - |
dc.contributor.AlternativeAuthor | 김용석 | - |
dc.contributor.AlternativeAuthor | 장미숙 | - |
dc.contributor.AlternativeAuthor | 박창환 | - |
dc.contributor.AlternativeAuthor | 이상훈 | - |
dc.identifier.doi | 10.1097/WNR.0b013e328340ccf9 | - |
dc.citation.journaltitle | Neuroreport | - |
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