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Development of 3-D poly(trimethylenecarbonate-co-epsilon-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning method

Cited 24 time in Web of Science Cited 27 time in Scopus
Authors
Shin, Teo Jeon; Park, Sook Young; Kim, Hyun Jeong; Lee, Hak Jun; Youk, Ji Ho
Issue Date
2010-06
Publisher
SPRINGER
Citation
BIOTECHNOLOGY LETTERS, Vol.32, No.6, pp.877-882
Keywords
BiomaterialsPoly(p-dioxanone)OsteoblastsBone regenerationCell movement
Abstract
The three dimensional (3-D) poly(trimethylenecarbonate-co-epsilon-caprolactone)-block-poly(p-dioxanone) scaffold was made using a wet electrospinning method and its application as a tissue engineered matrix was evaluated for bone regeneration. The scaffold was highly porous (90%) and interconnected among pores. Under scanning electron microscopy, the cells of the center of the scaffold showed healthy well attached shape even at 4 days after seeding. The osteoblastic MC3T3-E1 cells proliferated 1.2 times faster at 4 day, 1.5 times faster at 7 days after seeding as compared with the control in the scaffold (P < 0.05). The activity of alkaline phosphatase, a bone formation marker, of cells seeded in the scaffold was nearly four times faster compared to control 28 days after seeding (P < 0.05). Taken together, newly developed 3-D poly(trimethylenecarbonate-co-epsilon-caprolactone)-block-poly(p-dioxanone) scaffold is a promising candidate for bone regeneration.
ISSN
0141-5492
Language
English
URI
https://hdl.handle.net/10371/80367
DOI
https://doi.org/10.1007/s10529-010-0235-7
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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