S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 23 No.2 (1982)
LIthium Carbonate가 백서뇌내신경전달물질에 미치는 영향에 관한 실험적 연구
Effect of Lithium Carbonate on the Concentrations of Monoamine Neurotransmitters in the Rat Brain
- 이철; 이정균; 서유헌; 박찬웅
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.23 No.2, pp. 227-236
- An experimental study was performed to elucidate
the mechanism of therapeutic effect of lithium in
the manic-depressive illness using 174 male SpragueDawley
rats. The concentrations of lithium in plasma,
erythrocyte, and brain tissue and the concentrations
of norepinephrine, dopamine, and 5 hydroxytryptamine
in the whole brain of rats were measured following
single dose (3mM or/6mM kg. wt.) or repeated
administrations (3mM/kg/day, for 3 days, 7 days,
and 14 days) of lithium carbonate through mouth.
1. The correlation between plasma lithium and brain
lithium levels was slightly higher than that between
erythrocyte lithium and brain lithium levels.
2. Following single dose of lithium carbonate, the
concentrations of norepinephrine, dopamine and
5-hydroxytryptamine were not changed significantly
from those of the controis.
3. Following repeated administrations (more than 3
days) of lithium carbonate, the concentration of
5 hydroxytryptamine was significantly elevated,
but the concentrations of norepinephrine and
dopamine were not changed significantly from
those of controls.
4. When the lithium administrations were combined
with the intraperitoneal injection of a tyrosine
hydroxylase inhibitor, a-methylparatyrosine or a tryptophan hydroxylase inhibitor, para-chlorophenylalanine,
there was a tendency of elevation of
concentrations of all 3 amines.
Above results indicated that the plasma lithium
values reflected better the lithium concentration of
the brain than erythrocyte lithium values, and that
the lithium lowers the activities of norepinephrine,
dopamine and 5- hydroxytryptamine neurone in the
brain and may affect the synthesis of thess monoamines.
These lowering effect of lithium might be
related to the therapeutic effect of lithium in manicdepressive