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The phosphoinositide phosphatase Sac1 is required for midline axon guidance

Cited 5 time in Web of Science Cited 7 time in Scopus
Authors
Lee, Seongsoo; Kim, Sungdae; Nahm, Minyeop; Kim, Euijae; Yoon, Jin Ho; Lee, Seungbok; Kim, Tai-Il
Issue Date
2011-11
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS; Vol.32, No.5, pp.477-482
Keywords
Drosophilamidline axon guidancephosphoinositide phosphataseSac1
Abstract
Sac1 phosphoinositide (PI) phosphatases are important regulators of PtdIns(4)P turnover at the ER, Golgi, and plasma membrane (PM) and are involved in diverse cellular processes including cytoskeletal organization and vesicular trafficking. Here, we present evidence that Sac1 regulates axon guidance in the embryonic CNS of Drosophila. Sac1 is expressed on three longitudinal axon tracts that are defined by the cell adhesion molecule Fasciclin II (Fas II). Mutations in the sac1 gene cause ectopic midline crossing of Fas II-positive axon tracts. This phenotype is rescued by neuronal expression of wild-type Sac1 but not by a catalytically-inactive mutant. Finally, sac1 displays dosage-sensitive genetic interactions with mutations in the genes that encode the midline repellent Slit and its axonal receptor Robo. Taken together, our results suggest that Sac1-mediated regulation of PIs is critical for Slit/Robo-dependent axon repulsion at the CNS midline.
ISSN
1016-8478
Language
English
URI
https://hdl.handle.net/10371/80413
DOI
https://doi.org/10.1007/s10059-011-0168-6
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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