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Platelet-Rich Fibrin is a Bioscaffold and Reservoir of Growth Factors for Tissue Regeneration

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dc.contributor.authorKang, Young-Ho-
dc.contributor.authorJeon, Soung Hoo-
dc.contributor.authorPark, Joo-Young-
dc.contributor.authorChung, Jong-Hoon-
dc.contributor.authorChoung, Han-Wool-
dc.contributor.authorChoung, Pill-Hoon-
dc.contributor.authorKim, Eun-Suk-
dc.contributor.authorChoung, Yun-Hoon-
dc.date.accessioned2013-01-14T06:50:57Z-
dc.date.available2013-01-14T06:50:57Z-
dc.date.issued2011-02-
dc.identifier.citationTISSUE ENGINEERING PART A; Vol.17, No.3-4, pp.349-359ko_KR
dc.identifier.issn1937-3341-
dc.identifier.urihttps://hdl.handle.net/10371/80428-
dc.description.abstractThe platelet-rich fibrin (PRF) is known as a rich source of autologous cytokines and growth factors and universally used for tissue regeneration in current clinical medicine. However, the microstructure of PRF has not been fully investigated nor have been studied the key molecules that differ PRF from platelet-rich plasma. We fabricated PRF under Choukroun`s protocol and produced its extract (PRFe) by freezing at -80 degrees C. The conventional histological, immunohistological staining, and scanning electron microscopy images showed the microstructure of PRF, appearing as two zones, the zone of platelets and the zone of fibrin, which resembled a mesh containing blood cells. The PRFe increased proliferation, migration, and promoted differentiation of the human alveolar bone marrow stem cells (hABMSCs) at 0.5% concentration in vitro. From the results of proteome array, matrix metalloproteinase 9 (MMP9) and Serpin E1 were detected especially in PRFe but not in concentrated platelet-rich plasma. Simultaneous elevation of MMP9, CD44, and transforming growth factor beta-1 receptor was shown at 0.5% PRFe treatment to the hABMSC in immunoblot. Mineralization assay showed that MMP9 directly regulated mineralization differentiation of hABMSC. Transplantation of the fresh PRF into the mouse calvarias enhanced regeneration of the critical-sized defect. Our results strongly support the new characteristics of PRF as a bioscaffold and reservoir of growth factors for tissue regeneration.ko_KR
dc.language.isoenko_KR
dc.publisherMARY ANN LIEBERT INCko_KR
dc.titlePlatelet-Rich Fibrin is a Bioscaffold and Reservoir of Growth Factors for Tissue Regenerationko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor강영호-
dc.contributor.AlternativeAuthor전성후-
dc.contributor.AlternativeAuthor박주영-
dc.contributor.AlternativeAuthor정종훈-
dc.contributor.AlternativeAuthor정한울-
dc.contributor.AlternativeAuthor정필훈-
dc.contributor.AlternativeAuthor김은석-
dc.contributor.AlternativeAuthor정연훈-
dc.identifier.doi10.1089/ten.tea.2010.0327-
dc.citation.journaltitleTISSUE ENGINEERING PART A-
dc.description.tc3-
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