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Effect of hydroxyapatite-coated nanofibrous membrane on the responses of human periodontal ligament fibroblast

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dc.contributor.authorPark, Sun-Hye-
dc.contributor.authorKim, Tae-Il-
dc.contributor.authorKu, Young-
dc.contributor.authorYu, Ji-Hee-
dc.contributor.authorLee, Seung-Pyo-
dc.contributor.authorHan, Soo-Boo-
dc.contributor.authorChung, Chong-Pyoung-
dc.contributor.authorKim, Hae-Won-
dc.contributor.authorLee, Hae-Hyoung-
dc.date.accessioned2013-01-14T07:19:06Z-
dc.date.available2013-01-14T07:19:06Z-
dc.date.issued2008-01-
dc.identifier.citationJOURNAL OF THE CERAMIC SOCIETY OF JAPAN, Vol.116, No.1349, pp.31-35ko_KR
dc.identifier.issn1882-0743-
dc.identifier.urihttps://hdl.handle.net/10371/80462-
dc.description.abstractIn this study, hydroxyapatite-coated biopolymer nanofibrous membrane was synthesized by mineralizing the electrospun polycaprolactone nanofiber. The effect of the hydroxyapatite-coated nanofibrous membrane was mainly investigated on the proliferation and differentiation of human periodontal ligament fibroblast, which is necessary for periodontal tissue regeneration. Scanning electron microscopy revealed favorable cell attachment and spreading appearance on 1 d and MTS assay showed increased cell proliferation on the hydroxyapatite-coated nanofiber membrane during 14 d. From 7 to 14 d, alkaline phosphatase activity of the hydroxyapatite-coated nanofiber was significantly increased when compared to that of control group. Hydroxyapatite-coated nanofibrous membrane showed prominent mineral formation on day 14. As a result, it was clarified that the developed hydroxyapatite-coated nanofibrous membrane had favorable effects on the proliferation and differentiation of human periodontal ligament fibroblast and might be a good candidate material for periodontal tissue regeneration.ko_KR
dc.description.sponsorshipThis work was supported by Korea Research Foundation Grant funded by Korean Goverment (MOEHRD, Basic research promotion fund). (KRF-2005-003-E00255)-
dc.language.isoenko_KR
dc.publisherCERAMIC SOC JAPAN-NIPPON SERAMIKKUSU KYOKAIko_KR
dc.subjectbiomaterialko_KR
dc.subjecthydroxyapatiteko_KR
dc.subjectmembraneko_KR
dc.subjectperiodontal ligament fibroblastko_KR
dc.subjectperiodontal tissue regenerationko_KR
dc.titleEffect of hydroxyapatite-coated nanofibrous membrane on the responses of human periodontal ligament fibroblastko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박선혜-
dc.contributor.AlternativeAuthor김태일-
dc.contributor.AlternativeAuthor구영-
dc.contributor.AlternativeAuthor유지희-
dc.contributor.AlternativeAuthor이승표-
dc.contributor.AlternativeAuthor한수부-
dc.contributor.AlternativeAuthor정종평-
dc.contributor.AlternativeAuthor김해원-
dc.contributor.AlternativeAuthor이해형-
dc.identifier.doi10.2109/jcersj2.116.31-
dc.citation.journaltitleJOURNAL OF THE CERAMIC SOCIETY OF JAPAN-
dc.description.tc5-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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