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MUC1 expression in the oral mucosal epithelial cells of the elderly

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dc.contributor.authorChang, Woon-Ic-
dc.contributor.authorChang, Ji-Youn-
dc.contributor.authorKim, Yoon-Young-
dc.contributor.authorLee, Gene-
dc.contributor.authorKho, Hong-Seop-
dc.date.accessioned2013-01-14T07:21:22Z-
dc.date.available2013-01-14T07:21:22Z-
dc.date.issued2011-09-
dc.identifier.citationARCHIVES OF ORAL BIOLOGY, Vol.56, No.9, pp.885-890ko_KR
dc.identifier.issn0003-9969-
dc.identifier.urihttps://hdl.handle.net/10371/80465-
dc.description.abstractObjective: MUC1 is primarily involved in the protection of epithelial surfaces. Decreases in oral mucosal defence can be a predisposing factor for the development of oral mucosal diseases in the elderly. The aim of this study was to compare MUC1 expression level in oral mucosal epithelial cells of the elderly with that of young adults. Design: Thirty elderly (mean age, 71.1 +/- 4.6 years) and thirty young (mean age, 26.4 +/- 2.4 years) adults (15 men and 15 women in each group) were included. Oral examination, including tooth, periodontal, and oral mucosal status, was performed and whole saliva samples were collected along with flow rate measurements. Precipitates of stimulated whole saliva were used for the evaluation of MUC1 expression using real-time PCR. Clarified supernatants were used for the measurement of pro-inflammatory cytokines, IL-1 beta, IL-6, and TNF-alpha. Results: There was a significant decrease in the amounts of MUC1 transcripts in elderly subjects compared with those of young subjects, a result seen in both men (0.589-fold) and women (0.547-fold). The MUC1 expression level was not correlated with salivary cytokine level but did show a significant positive correlation with the level of periodontal inflammation (r(s) = 0.505, P < 0.01) in the elderly group. Conclusions: Oral mucosal defence provided by MUC1 was decreased in the elderly; this decrease may play a role in the development of oral mucosal diseases in the aged population. (C) 2011 Elsevier Ltd. All rights reserved.ko_KR
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea Grant funded by the Korean Government through the Oromaxillofacial Dysfunction Research Centre for the Eldely (No. 2010-0029478) at Seoul National University in Korea.-
dc.language.isoenko_KR
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDko_KR
dc.subjectMUC1ko_KR
dc.subjectElderlyko_KR
dc.subjectOral epithelial cellko_KR
dc.subjectSalivako_KR
dc.titleMUC1 expression in the oral mucosal epithelial cells of the elderlyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor장원익-
dc.contributor.AlternativeAuthor장지연-
dc.contributor.AlternativeAuthor김윤영-
dc.contributor.AlternativeAuthor이진-
dc.contributor.AlternativeAuthor고홍섭-
dc.identifier.doi10.1016/j.archoralbio.2011.02.007-
dc.citation.journaltitleARCHIVES OF ORAL BIOLOGY-
dc.description.tc1-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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