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나균 및 기타 9종의 Mycobacteria 세포벽항원에 대한 나환자의 피뇌반응 비교연구
A Comparative Study on the Dermal Reactions in Leprosy Patients to the Cell Wall Antigens of Mycobacterium Leprae and other 9 Species of Mycobacteria

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Issue Date
1982-09
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.23 No.3, pp. 323-333
Abstract
The present study was carried out to investigate
the specificity of cell wall antigen of M. leprae and
to access the degree of association in the dermal
reactions of leprosy patients to the cell wall antigens.
of 10 species of mycobacteria including M. leprae.
The cell wall antigens were prepared from M. leprae,
M. kansasii, M. vaccae. M. marinum, M. scrofulaseum,
M. tuberculosis, M. fortuitum, M. phlei, M. smegmatis
and Bacillus Calmette Guerin by passing 5 timesthrough
a French Pressure Cell Press at 18,000 lbs/
inch",
The mycobacterial cell wall antigens were injected
intradermally on 124 leprosy patients(77 lepromatous.
and 47 tuberculoid) and the results of the early(Fe·
rnandez) and the late (Mitsuda) reactions were recorded
72 hours and 28 days later, respectively.
The results were summarized as follows;
1. The deficiency of the early(Fernandezl and the
late (Mitsuda) reactivity in lepromatous type patients
to mycobacterial cell wall antigens was species
specific for M. leprae.
2. The reactivities of lepromatous type patients tocell
wall antigens of 10 species of mycobacteria'
were generally lower than those of tuberculoid'
patients.
3. In the early(Fernandez) reaction of 124 leprosy
patients to cell wall antigens, M. leprae showed' significant association (p<0.05) with M. kansasii,
M. VQccae, M. smegmatis, M. phlei, M. marinum
and M. fortuitum. And in late (Mitsuda) reaction,
M. leprae showed significant associationtp-C
0.05) with M. phlei, M. f'ortuitum and M. kansasii,
Of the mycobacteria, which showed significant
association in the early (Fernandez) and in
the late (Mitsuda) reactions, M. f'ortuitum showed
the highest sensitivity and M. kansasii the highest
specificity.
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/8048
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 23 No.3 (1982)
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