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Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib

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dc.contributor.authorLee, Sin-Ae-
dc.contributor.authorLee, Mi-Sook-
dc.contributor.authorRyu, Hyung Won-
dc.contributor.authorKwak, Tae Kyoung-
dc.contributor.authorKang, Minkyung-
dc.contributor.authorKim, Hyun Jeong-
dc.contributor.authorLee, Jung Weon-
dc.contributor.authorPark, Ki Hun-
dc.contributor.authorJung, Oisun-
dc.contributor.authorKim, Hyeonjung-
dc.date.accessioned2013-01-15T00:30:52Z-
dc.date.available2013-01-15T00:30:52Z-
dc.date.issued2011-02-01-
dc.identifier.citationCANCER BIOLOGY & THERAPY, Vol.11, No.3, pp.330-336ko_KR
dc.identifier.issn1538-4047-
dc.identifier.urihttps://hdl.handle.net/10371/80534-
dc.description.abstractTwo separate clinical studies of advanced hepatocarcinoma patients recently reported that the multikinase inhibitor sorafenib (nexavar) could extend survival of the patients only by 2-3 months. We also previously demonstrated that 4`-(p-toluenesulfonylamido)-4-hydroxychalcone (TSAHC) blocks the multilayer growth and migration mediated by TM4SF5, which is highly expressed in approximately 80% of Korean hepatocarcinoma patients. Therefore, we wondered how TSAHC might be different from sorafenib to deal with hepatocarcinoma in terms of the therapeutic characteristics including specificity for TM4SF5. TM4SF5 is previously shown to mediate tumorigenesis through cytosolic p27(Kip1)-mediated inactivation of RhoA, epithelial-mesenchymal transition, multilayer growth, migration, invasion and tumor angiogenesis. In this study, TSAHC and two derivatives showed similar antagonistic activities against TM4SF5-mediated signaling and multilayer growth in vitro and anti-tumorigenic activity even in early stages of TM4SF5-mediated tumor formation in nude mice. Meanwhile, sorafenib was only effective much later in tumorigenesis in vivo and affected in vitro proliferation in a TM4SF5-independent manner. Altogether, these observations suggest that TSAHC may be a promising anti-tumorigenic reagent, especially against TM4SF5-mediated hepatocarcinoma.ko_KR
dc.language.isoenko_KR
dc.publisherLANDES BIOSCIENCEko_KR
dc.subjectcontact inhibitionko_KR
dc.subjectTM4SF5ko_KR
dc.subjectsorafenibko_KR
dc.subjectliver carcinomako_KR
dc.subjectanti-tumorigenic reagentko_KR
dc.titleDifferential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenibko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor이미숙-
dc.contributor.AlternativeAuthor류형원-
dc.contributor.AlternativeAuthor곽태경-
dc.contributor.AlternativeAuthor강민경-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor이정원-
dc.contributor.AlternativeAuthor박기훈-
dc.contributor.AlternativeAuthor정외선-
dc.contributor.AlternativeAuthor김현정-
dc.identifier.doi10.4161/cbt.11.3.14099-
dc.citation.journaltitleCANCER BIOLOGY & THERAPY-
dc.description.tc1-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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