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Effects of Saccharin Intake on Hippocampal and Cortical Plasticity in Juvenile and Adolescent Rats

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Park, Jong-Sil; Yoo, Sang Bae; Kim, Jin Young; Lee, Sung Joong; Kim, Joong-Soo; Park, Kyungpyo; Choi, Se-Young; Jahng, Jeong Won; Lee, Jong-Ho; Oh, Seog-Bae
Issue Date
2010-04
Publisher
The Korean Physiological Society & the Korean
Citation
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.14, No.2, pp.113-118
Keywords
HippocampusTasteSynaptic plasticitySomatosensory cortexSensory overloadingExperience dependency
Abstract
The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have revealed that deprivation of specific sensory experiences can modify the structure and function of the central nervous system; however, the effects of sensory overload remains unclear. H ere we studied the effect of overloading the taste sense in the early period of life on the synaptic plasticity of rat hippocampus and somatosensory cortex. We prepared male and female Sprague Dawley rats with ad libitum access to a 0.1% saccharin solution for 2 hrs per day for three weeks after weaning on postnatal day 22. Saccharin consumption was slightly increased in males compared with females; however, saccharin intake did not affect chow intake or weight gain either in male or in female rats. We examined the effect of saccharin-intake on long term potentiation (LTP) formation in hippocampal Schaffer collateral pathway and somatosensory cortex layer IV - II/III pathways in the 6-week old saccharin-fed rats. There was no significant difference in LTP formation in the hippocampus between the control group and saccharin-treated group in both male and female rats. Also in the somatosensory cortex, we did not see a significant difference in LTP among the groups. Therefore, we conclude that saccharin-intake during 3 similar to 6 weeks may not affect the development of physiological function of the cortical and hippocampal synapses in rats.
ISSN
1226-4512
Language
English
URI
http://hdl.handle.net/10371/80563
DOI
https://doi.org/10.4196/kjpp.2010.14.2.113
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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