골수의 비만세포에 대한 관찰

Abstract

have been observed in a wide variety of hematologic disorders, as well as in several nonhematologic disease states. However, the frequency and significance of this phenomenon in the bone marrow has not yet been accurately determined. In an attemp to define the disorders associated with an increase in bone marrow mast cells and to assess the relative incidence of this finding, we examined 220 bone marrow sections obtained at the Department of Laboratory Medicine, Seoul National University Hospital for 7 months from Jan. 1982 to July 1982. Mast cells were adjudged by the metachromatic staining of their cytoplasmic granules and counted in 20 fields under dry high power(X 400). The 220 sections were divided into four groups according to the mast cell counts/ HPF. Group 1 : Group n: GroupM: GroupN: The results obtained were as follows: 1. The mast cells were irregularly dispersed between hemopoietic cells, fat globules and around blood vessels. 2. Mast cells were increased in 15(6.82%) out of 220 bone marrow sections. 3. There was statistically significant difference between the groups having increased number of mast cells and having normal number of mast cells in celluarity (p<O. 05). 4. Of the 15 patients belonging group III (12 case) and IV (3 case), six had aplastic anemia, three had iron deficiency anemia, and each one with systemic lupus erythematQsus, hypersplenism, preleukemic syndrome, FDO, systemic bacterial infection, and malignant lymphoma without bone marrow metastasis. 5. Of the 30 patients who had aplastic anemia, eleven were group I. thirteen were group II, four were group III and two were group IV. 6. None of the 44 patients with leukemia have (AML 23, CML 9, ALL 12) increased mast cells. 7. There was no consistent relationship between the presence of increased number of mast cells and iron contents, and M;E ratio. 8. In group III and IV, anemia was the sole common factor, but there was no significant relationship between the degree of anemia and the presence of increased number of mast cells.