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The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Seung-Ki | - |
dc.contributor.author | Lee, Sang-Chul | - |
dc.contributor.author | Hong, Seong-Doo | - |
dc.contributor.author | Chung, Chong-Pyoung | - |
dc.contributor.author | Min, Byung-Moo | - |
dc.contributor.author | Park, Won Ho | - |
dc.date.accessioned | 2013-01-21T02:40:05Z | - |
dc.date.available | 2013-01-21T02:40:05Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Biomaterials; Vol.31, No.17, pp.4725-4730 | ko_KR |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80831 | - |
dc.description.abstract | Considerable effort has been directed towards regenerating defective tissues using tissue-engineering methods. Recently, peptides have been recognized as a valuable scientific tool in the field of tissue-engineering. The PPFLMLLKGSTR motif of the human laminin-5 alpha3 chain has been previously reported to promote keratinocyte survival; however, the in vivo effects of the PPFLMLLKGSTR motif have not yet been studied. These studies raised the hypothesis that a laminin-5-derived peptide can promote wound healing by accelerating re-epithelialization in vivo. To examine this hypothesis, we applied chitin microfibrous matrices coated with the PPFLMLLKGSTR motif in both rat and rabbit full-thickness cutaneous wound models. Compared with vehicle-treated and peptide-treated cutaneous wounds, the application significantly promoted early-stage wound healing by accelerating re-epithelialization, notably reduced inflammatory cell infiltration, and prominently enhanced fibroblast proliferation. These findings support our hypothesis that the PPFLMLLKGSTR motif acts as a very effective wound healing accelerator by enhancing re-epithelialization. ⓒ 2010 Elsevier Ltd. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Elsevier | ko_KR |
dc.subject | Laminin-5-derived peptide | ko_KR |
dc.subject | Wound healing | ko_KR |
dc.subject | Wound dressing material | ko_KR |
dc.subject | Re-epithelialization | ko_KR |
dc.subject | Tissue-engineering | ko_KR |
dc.title | The effect of a laminin-5-derived peptide coated onto chitin microfibers on re-epithelialization in early-stage wound healing | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 민승기 | - |
dc.contributor.AlternativeAuthor | 이상철 | - |
dc.contributor.AlternativeAuthor | 홍성두 | - |
dc.contributor.AlternativeAuthor | 정종평 | - |
dc.contributor.AlternativeAuthor | 민병호 | - |
dc.contributor.AlternativeAuthor | 박원호 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2010.02.045 | - |
dc.citation.journaltitle | Biomaterials | - |
dc.description.tc | 2 | - |
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