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Relationship between the expressions of PD-L1 and tumor-infiltrating lymphocytes in oral squamous cell carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Young-Ah | - |
dc.contributor.author | Yoon, Hye-Jung | - |
dc.contributor.author | Lee, Jae-Il | - |
dc.contributor.author | Hong, Sam-Pyo | - |
dc.contributor.author | Hong, Seong-Doo | - |
dc.date.accessioned | 2013-01-21T03:52:28Z | - |
dc.date.available | 2013-01-21T03:52:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Oral Oncology; Vol.47, No.12, pp.1148-1153 | ko_KR |
dc.identifier.issn | 1368-8375 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80837 | - |
dc.description.abstract | Tumor-infiltrating lymphocytes (TILs) are considered to represent immune reactions of the host to a malignant tumor. Programmed death receptor ligand-1 (PD-L1) is a surface protein that blocks the function of T lymphocytes and is expressed on cancer cells. Tumor-associated fibroblasts (TAFs), which influence tumor growth have also been reported to express PD-L1 and thus inhibit TILs. In the present study, we investigated the densities of CD4 +/CD8 + TILs, PD-L1 expression of tumor cells and TAFs in oral squamous cell carcinoma (OSCC). Forty-five cases of OSCC were selected. We evaluated PD-L1 expression and the infiltration degree of each lymphocyte by immunohistochemical examination. These data were analyzed in connection with clinicopathological factors. Peritumoral CD8 + TILs were observed in every patient with OSCC, and their densities were correlated with lymph node metastasis (P < 0.001), tumor size (P = 0.003), and clinical stage (P < 0.001). PD-L1 expression on OSCC cells was observed in 39 cases and was associated with the lower density of intratumoral CD8 + TILs (P = 0.047). PD-L1 expression of tumors <4 cm in size was correlated with the histological grade of the tumor (P = 0.022). TAFs were positive for PD-L1 in 18 cases. Peritumoral TILs were significantly associated with tumor size, lymph node metastasis and clinical stage. Though PD-L1 expressed by OSCC cells did not affect patients` survival, its correlation with decreased number of intratumoral TILs suggests that the development of a strategy to block the interactions of PD-L1 with TIL would be a useful tool for inhibiting tumor growth. ⓒ 2011 Elsevier Ltd. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Elsevier | ko_KR |
dc.subject | Cancer immunity | ko_KR |
dc.subject | PD-L1 | ko_KR |
dc.subject | Tumor-associated fibroblasts | ko_KR |
dc.subject | Oral squamous cell carcinoma | ko_KR |
dc.subject | CD8 + lymphocytes | ko_KR |
dc.subject | Tumor-infiltrating lymphocytes | ko_KR |
dc.title | Relationship between the expressions of PD-L1 and tumor-infiltrating lymphocytes in oral squamous cell carcinoma | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조영아 | - |
dc.contributor.AlternativeAuthor | 윤혜정 | - |
dc.contributor.AlternativeAuthor | 이재일 | - |
dc.contributor.AlternativeAuthor | 홍삼표 | - |
dc.contributor.AlternativeAuthor | 홍성두 | - |
dc.identifier.doi | 10.1016/j.oraloncology.2011.08.007 | - |
dc.citation.journaltitle | Oral Oncology | - |
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