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Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients

Cited 68 time in Web of Science Cited 71 time in Scopus
Authors
Jang, M.-U.; Park, J.-W.; Kho, H.-S.; Chung, S.-C.; Chung, Jin-Woo
Issue Date
2011
Publisher
John Wiley & Sons
Citation
Oral Diseases; Vol.17, No.2, pp.187-193
Keywords
Calcitonin-gene related peptideChronic migrainePlasma, salivaSubstance PNerve growth factor
Abstract
Objectives: To investigate the level and interrelationship of nerve growth factor (NGF) and sensory neuropeptides [substance P (SP), calcitonin gene-related peptide (CGRP)] in plasma and saliva of chronic migraine patients, and to analyze the association between pain intensity and their concentration. Materials and methods: Plasma and resting whole saliva were collected from 33 chronic migraine patients and 36 control subjects. NGF, SP, and CGRP concentrations were measured by enzyme immunoassay and pain intensity of each subject was measured using the Graded Chronic Pain Scale. Results: Chronic migraine patients showed higher NGF and neuropeptide levels in both plasma and saliva compared to the control subjects. Plasma NGF, and plasma and saliva levels of SP and CGRP were highly associated with pain intensity. There was a significant positive correlation between NGF and both neuropeptide levels in plasma, and between the neuropeptide levels in both plasma and saliva. Plasma levels of SP and CGRP were significantly correlated with their saliva level. Conclusions: The increased production of NGF and sensory neuropeptides may play an important role in the maintenance of pain in chronic migraine and analysis results of human saliva could act as an index of disease state and therapeutic outcome. ⓒ 2010 John Wiley & Sons A/S.
ISSN
1354-523X
Language
English
URI
https://hdl.handle.net/10371/80898
DOI
https://doi.org/10.1111/j.1601-0825.2010.01717.x
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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