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Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells

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dc.contributor.authorJung H.-S.-
dc.contributor.authorLee D.-S.-
dc.contributor.authorLee J.-H.-
dc.contributor.authorPark S.-J.-
dc.contributor.authorSeo B.-M.-
dc.contributor.authorPark J.-C.-
dc.contributor.authorKo J.S.-
dc.contributor.authorLee G.-
dc.date.accessioned2013-01-22T01:04:28Z-
dc.date.available2013-01-22T01:04:28Z-
dc.date.issued2011-
dc.identifier.citationJournal of Molecular Histology, Vol.42, No.3, pp.227-235ko_KR
dc.identifier.issn1567-2379-
dc.identifier.urihttps://hdl.handle.net/10371/80914-
dc.description.abstractIt is known that the dental follicle (DF) consists of progenitor cells that give rise to the cementum, periodontal ligament, and alveolar bone; but little information is available about the regulation of DF cell differentiation into either cementogenic or osteogenic cell lineages for the regeneration of diseased periodontal tissue. Here, we investigated the roles of DF, Hertwig`s epithelial root sheath (HERS), and pulp cells in the cementum and during alveolar bone formation. We cultured these cells; transplanted them alone or in combination into immunocompromised mice; and observed their effects at 6 and 12 weeks. Histological and immunohistochemical results revealed that DF cells formed cementum-like tissues with immunoreactivity to cementum-derived attached protein, bone sialoprotein, type I collagen, and alkaline phosphatase. In addition, HERS cells played a role in the induction and maturation of cementum-like tissues formed by DF cells. In contrast, implants of DF cells in the presence of pulp cells led to the formation of bone-like tissues. Interestingly, in the presence of both HERS and pulp cells, DF cells formed both cementum-like and bone-like tissues. We demonstrated that while HERS cells are able to induce DF cell differentiation into cementoblasts and promote cementum formation, pulp cells could direct DF cell differentiation into osteoblasts and enhance alveolar bone formation. These results suggest that the combined use of DF, HERS, and pulp cells could direct DF cell differentiation into cementoblasts and/or osteoblasts in vivo, thus providing a novel strategy for the successful repair and regeneration of diseased periodontal tissue. (c) 2011 Springer Science+Business Media B.V.ko_KR
dc.description.sponsorshipThis study was supported by a grant of the
Korea Healthcare Technology R&D Project, Ministry of Health, Welfare & Family Affairs, Republic of Korea (A084701).
ko_KR
dc.language.isoenko_KR
dc.publisherSpringer Verlagko_KR
dc.subjectAlveolar boneko_KR
dc.subjectCementumko_KR
dc.subjectDental follicle cellko_KR
dc.subjectPulp cellko_KR
dc.subjectHERSko_KR
dc.titleDirecting the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor정현성-
dc.contributor.AlternativeAuthor이동설-
dc.contributor.AlternativeAuthor이지현-
dc.contributor.AlternativeAuthor박수진-
dc.contributor.AlternativeAuthor서병무-
dc.contributor.AlternativeAuthor박주철-
dc.contributor.AlternativeAuthor고재승-
dc.contributor.AlternativeAuthor이진-
dc.identifier.doi10.1007/s10735-011-9327-5-
dc.citation.journaltitleJournal of Molecular Histology-
dc.description.tc4-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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