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Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-κB in mouse skin by blocking IκB kinase activity : Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappa B in mouse skin by blocking I kappa B kinase activity
DC Field | Value | Language |
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dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Kim, Sung Hoon | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2013-01-22T02:16:22Z | - |
dc.date.available | 2013-01-22T02:16:22Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | Carcinogenesis, Vol.27 No.7, pp.1465-1474 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.other | 3700 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80928 | - |
dc.description.abstract | Aberrant expression of cyclooxygenase-2 (COX-2) has been implicated in tumor promotion. Resveratrol, a phytoalexin present in grapes, was reported to inhibit multistage mouse skin carcinogenesis. In the present study, we found that topically applied resveratrol significantly inhibited COX-2 expression induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Resveratrol-suppressed phosphorylation and subsequent degradation of I kappa B alpha, thereby inhibiting activation of nuclear factor-kappa B (NF-kappa B) in TPA-stimulated mouse skin. Pretreatment with resveratrol also suppressed TPA-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) and p38 mitogen-activated protein (MAP) kinase. Resveratrol blunted TPA-induced phosphorylation of p65 and its interaction with CBP/p300, rendering NF-kappa B transcriptionally inactive. To get further insights into the molecular basis of NF-kappa B inactivation by resveratrol, we examined the role of I kappa B kinase (IKK) in mediating TPA-induced activation of NF-kappa B and COX-2 expression. TPA treatment led to rapid induction of IKK activity in mouse skin, which was abolished either by resveratrol or an IKK inhibitor Bay 11-7082. Topical application of Bay 11-7082 also abrogated TPA-induced NF-kappa B activation and COX-2 expression, supporting the involvement of IKK in TPA-induced COX-2 expression. Taken together, the above findings suggest that resveratrol targets IKK in blocking TPA-induced NF-kappa B activation and COX-2 expression in mouse skin in vivo. | - |
dc.language | 영어 | - |
dc.language.iso | en | ko_KR |
dc.publisher | Oxford University Press | - |
dc.title | Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-κB in mouse skin by blocking IκB kinase activity | - |
dc.title.alternative | Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappa B in mouse skin by blocking I kappa B kinase activity | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1093/carcin/bgi349 | - |
dc.citation.journaltitle | Carcinogenesis | - |
dc.description.tc | 83 | - |
dc.identifier.wosid | 000238906200020 | - |
dc.identifier.scopusid | 2-s2.0-33745728903 | - |
dc.citation.endpage | 1474 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 1465 | - |
dc.citation.volume | 27 | - |
dc.identifier.sci | 000238906200020 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Shin, Young Kee | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVITY | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | POTENTIAL ROLE | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | P65 SUBUNIT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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