Responses of periodontal ligament stem cells on various titanium surfaces

Cited 21 time in Web of Science Cited 22 time in Scopus

Heo, Y.-Y.; Um, S.; Kim, S.-K.; Park, J.-M.; Seo, Byoung Moo

Issue Date
John Wiley and Sons
Oral Diseases, Vol.17, No.3, pp.320-327
Dental implantPeriodontal ligament stem cellOsteocalcinTitanium surface
OBJECTIVE: Periodontal ligament has been reported to have adult stem cells (PDLSCs) which are responsible to regenerate the alveolar bone tissue after tooth is removed from its socket. Also PDLSCs may be the stem cells responsible for the osseointegration of titanium implants after installing the implant immediately in the fresh extracted socket. Here we tested cellular responses of PDLSCs on the various titanium surfaces to verify this notion.
MATERIALS AND METHODS: Titanium disc were
prepared for the different surface textures; smooth machined, blasted with 75 and 125 μm Al2 O3 particles, and anodized. PDLSCs were cultured on these titanium discs and tested their proliferation and gene expressions of osteocalcin, osteopontin, type I collagen, and GAPDH.
RESULTS: Proliferation of PDLSCs was higher on the rough surface blasted with 75 μm Al2
O3 particles. Osteocalcin expression was increased on the Al2O3 particle treated-surface regardless of its particle size. Type I collagen expression was generally decreased with time in 6 days culture.
CONCLUSIONS: In this experiment, it was shown that cultured PDLSCs proliferate in higher rate on the rough surface especially at the 75 μm Al2O3 particle treated surface than other surfaces. Also, osteocalcin was highly expressed on the rough surfaces treated with 75 μm and 125 μm Al2O3 particles.
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.