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Involvement of promyelocytic leukemia protein in the ethanol-induced apoptosis in mouse embryo fibroblasts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Li-Hui | - |
dc.contributor.author | Yang, Jing-Yu | - |
dc.contributor.author | Cui, Wei | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Wu, Chun-Fu | - |
dc.date.accessioned | 2013-01-22T06:13:51Z | - |
dc.date.available | 2013-01-22T06:13:51Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN; Vol.128, No.7, pp.1067-1071 | ko_KR |
dc.identifier.issn | 0031-6903 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80966 | - |
dc.description.abstract | The promyelocytic leukemia (PML) gene is a tumor suppressor gene associated with cell apoptosis, cell proliferation, and senescence. However, the role of PML in the ethanol-induced apoptosis is not fully-known. In this study, using wild-type mouse embryo fibroblasts (MEF) and PML null MEF cells, we found that (1) ethanol (100 mM and 200 mM) could obviously induce apoptosis of wild-type MEF cells, whereas, in PML null MEF cells, the pro-apoptotic function of ethanol was partially blocked; (2) the expression levels of phosphorylated p53 and two of its target genes, p21 and Bax, could be significantly up-regulated by ethanol (200 mM) in wild-type MEF cells in a time-dependent manner, but not in PML null MEF cells. These results indicate that PML plays an important role in ethanol-induced apoptosis, and p53-dependent apoptotic pathway may be involved in this process. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PHARMACEUTICAL SOC JAPAN | ko_KR |
dc.subject | promyelocytic leukemia protein | ko_KR |
dc.subject | apoptosis | ko_KR |
dc.subject | ethanol | ko_KR |
dc.title | Involvement of promyelocytic leukemia protein in the ethanol-induced apoptosis in mouse embryo fibroblasts | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 신영기 | - |
dc.identifier.doi | 10.1248/yakushi.128.1067 | - |
dc.citation.journaltitle | YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | - |
dc.description.tc | 1 | - |
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