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Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

Cited 109 time in Web of Science Cited 110 time in Scopus
Authors
Hong, Kyoung-Ok; Kim, Ji-Hong; Hong, Ji-Soo; Yoon, Hye-Jung; Hong, Sam-Pyo; Hong, Seong-Doo; Lee, Jae-Il
Issue Date
2009
Publisher
BioMed Central
Citation
Journal of Experimental and Clinical Cancer Research; Vol.28, No.1
Abstract
The Akt/PKB family of kinases is frequently activated in human cancers, including oral squamous cell carcinoma (OSCC). Akt-induced epithelial-to-mesenchymal transition (EMT) involves downregulation of E-cadherin, which appears to result from upregulation of the transcription repressor Snail. Recently, it was proposed that carcinoma cells, especially in metastatic sites, could acquire the mesenchymal-to-epithelial reverting transition (MErT) in order to adapt the microenvironments and re-expression of E-cadherin be a critical indicator of MErT. However, the precise mechanism and biologic or clinical importance of the MErT in cancers have been little known. This study aimed to investigate whether Akt inhibition would restore the expression of E-cadherin and beta-catenin, reduce that of Vimentin, and induce the MErT in OSCC cells with low or negative expression of E-cadherin. We also investigate whether inhibition of Akt activity would affect the E-cadherin repressors and signaling molecules like NF-kappaB, ERK, and p38.
ISSN
1756-9966
Language
English
URI
https://hdl.handle.net/10371/80969
DOI
https://doi.org/10.1186/1756-9966-28-28
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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