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The Bone Regenerative Effect of Platelet-Derived Growth Factor-BB Delivered with a Chitosan/Tricalcium Phosphate Sponge Carrier
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong-Moo | - |
dc.contributor.author | Park, Yoon-Jeong | - |
dc.contributor.author | Lee, Seung-Jin | - |
dc.contributor.author | Ku, Young | - |
dc.contributor.author | Klokkevold, Perry R. | - |
dc.contributor.author | Chung, Chong-Pyoung | - |
dc.contributor.author | Han, Soo-Boo | - |
dc.date.accessioned | 2013-01-23T07:02:38Z | - |
dc.date.available | 2013-01-23T07:02:38Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Journal of Periodontology, Vol.71, No.3, pp.418-424 | ko_KR |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81047 | - |
dc.description.abstract | Background: In order to achieve optimal effects, growth factors including platelet-derived growth factor (PDGF) should be delivered with a biodegradable carrier that will release therapeutic concentrations over a sufficient length of time. The purpose of this study was to evaluate the bone regenerative effect of PDGF-BB delivered with a chitosan/tricalcium phosphate (TCP) sponge carrier in a rat calvarial defect model. Methods: The PDGF-BB-loaded chitosan/TCP sponge carrier was fabricated by freeze-drying a mixture of chitosan solution and TCP powder and soaking in a PDGF-BB solution. The release kinetics of PDGF-BB loaded onto the sponge were measured in vitro with 125I-labeled PDGF-BB. Chitosan/TCP sponges with and without PDGF-BB were implanted into 8 mm calvarial defects in rats. Rats were sacrificed at 2 and 4 weeks following implantation, and histologic and histomorphometrical examinations were performed. Results: In vitro evaluation demonstrated that an effective therapeutic concentration of PDGF-BB following a high initial burst release was maintained throughout the examination period. In the histologic examination, the chitosan/TCP sponge carrier promoted osseous healing of the rat calvarial defects as compared to controls. The addition of PDGF-BB to the carrier further enhanced bone regeneration. Evidence of the degraded sponge matrix was observed mingled within the newly formed bone without connective tissue encapsulation. Conclusions: The results of this study support the use of chitosan/TCP sponges as a delivery system for growth factors and demonstrate that PDGF-BB loaded onto chitosan/TCP sponge carriers has an osteogenic effect on bone regeneration in vivo. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | American Academy of Periodontology | ko_KR |
dc.subject | Animal studies | ko_KR |
dc.subject | Tissue engineering | ko_KR |
dc.subject | Tricalcium phosphate | ko_KR |
dc.subject | Sponges, artificial | ko_KR |
dc.subject | Bone regeneration | ko_KR |
dc.subject | Chitosan | ko_KR |
dc.subject | Growth factors, platelet-derived | ko_KR |
dc.subject | Bone development | ko_KR |
dc.title | The Bone Regenerative Effect of Platelet-Derived Growth Factor-BB Delivered with a Chitosan/Tricalcium Phosphate Sponge Carrier | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이용무 | - |
dc.contributor.AlternativeAuthor | 박윤정 | - |
dc.contributor.AlternativeAuthor | 이승진 | - |
dc.contributor.AlternativeAuthor | 구영 | - |
dc.contributor.AlternativeAuthor | 정종평 | - |
dc.contributor.AlternativeAuthor | 한수부 | - |
dc.identifier.doi | 10.1902/jop.2000.71.3.418 | - |
dc.citation.journaltitle | Journal of Periodontology | - |
dc.description.tc | 57 | - |
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