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Diffusion tensor imaging and fiber tractography in cervical compressive myelopathy: preliminary results

Cited 56 time in Web of Science Cited 61 time in Scopus
Authors
Lee, Joon Woo; Kim, Jae Hyoung; Park, Jong Bin; Park, Kun Woo; Yeom, Jin S.; Lee, Guen Young; Kang, Heung Sik
Issue Date
2011-12
Publisher
SPRINGER
Citation
SKELETAL RADIOLOGY Vol.40 No.12, pp. 1543-1551
Keywords
복합학
Abstract
To assess diffusion tensor imaging (DTI) parameters in cervical compressive myelopathy (CCM) patients compared to normal volunteers, to relate them with myelopathy severity, and to relate tractography patterns with postoperative neurologic improvement.Twenty patients suffering from CCM were prospectively enrolled (M:F = 13:7, mean age, 49.6 years; range 22-67 years) from September 2009 to March 2010. Sensitivity encoding (SENSE) single-shot echo-planar imaging (EPI) was used for the sagittal DTI. Twenty sex- and age-matched normal volunteers underwent the same scanning procedure. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in the spinal cord were compared between the patients and normal volunteers and were related to myelopathy severity based on Japanese Orthopedic Association (JOA) scores. Tractography patterns were related to myelopathy severity and postoperative improvement.There were significant differences between patients and normal volunteers in terms of FA (0.498 +/- 0.114 vs. 0.604 +/- 0.057; p = 0.001) and ADC (1.442 +/- 0.389 vs. 1.169 +/- 0.098; p = 0.001). DTI parameters and tractography patterns were not related to myelopathy severity. In ten patients in the neurologically worse group, postoperative neurologic improvement was seen in four of five patients with intact fiber tracts, but only one of five patients with interrupted fiber tracts exhibited neurologic improvement.DTI parameters in CCM patients were significantly different from those in normal volunteers but were not significantly related to myelopathy severity. The patterns of tractography appear to correlate with postoperative neurologic improvement.
ISSN
0364-2348
Language
English
URI
https://hdl.handle.net/10371/81095
DOI
https://doi.org/10.1007/s00256-011-1161-z
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College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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