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Nonalcoholic fatty liver disease is associated with coronary artery calcification

Cited 180 time in Web of Science Cited 187 time in Scopus
Authors
Kim, Donghee; Choi, Su-Yeon; Park, Eun Ha; Lee, Whal; Kang, Jin Hwa; Kim, Won; Kim, Yoon Jun; Yoon, Jung-Hwan; Jeong, Sook Hyang; Lee, Dong Ho; Lee, Hyo-suk; Larson, Joseph; Therneau, Terry M.; Kim, W. Ray
Issue Date
2012-09
Publisher
Wiley-Blackwell
Citation
HEPATOLOGY Vol.56 No.2, pp. 605-613
Keywords
복합학
Abstract
Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)-measured visceral adiposity. Out of 5,648 subjects who visited one of our health screening centers between 2003 and 2008, we enrolled 4,023 subjects (mean age, 56.9 +/- 9.4 years; 60.7% males) without known liver disease or a history of ischemic heart disease. CAC score was evaluated using the Agatston method. On univariate analysis, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein cholesterol, triglycerides, and increased risk of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10-100, >= 100) were associated with higher prevalence of NAFLD (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.61-2.10; P<0.001). Multivariable ordinal regression analysis was adjusted for traditional risk factors, and CT-measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR, 1.28, 95% CI, 1.04-1.59; P = 0.023) independent of visceral adiposity. Conclusion: Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD might be an independent risk factor for coronary artery disease. (HEPATOLOGY 2012)
ISSN
0270-9139
Language
English
URI
http://hdl.handle.net/10371/81528
DOI
https://doi.org/10.1002/hep.25593
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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