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Non-alcoholic fatty liver disease across the spectrum of hypothyroidism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Goh Eun | - |
dc.contributor.author | Kim, Donghee | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Yim, Jeong Yoon | - |
dc.contributor.author | Park, Min Jung | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.creator | 윤정환 | - |
dc.date.accessioned | 2013-03-29T04:12:34Z | - |
dc.date.available | 2013-03-29T04:12:34Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | JOURNAL OF HEPATOLOGY Vol.57 No.1, pp. 150-156 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81529 | - |
dc.description.abstract | Background Aims: The aim of this study was to characterize the relationship between the broad spectrum of hypothyroidism and NAFLD.Methods: A cross-sectional study with 4648 health check-up subjects (2324 cases with hypothyroidism vs. age- and sex-matched controls) was conducted. The subjects were categorized as having either subclinical [thyroid-stimulating hormone (TSH) >= 4.1 mIU/L and normal free thyroixine (T-4) level (0.7-1.8 ng/dl)] or overt hypothyroidism [free T-4 < 0.7 ng/dl]. NAFLD was diagnosed on the basis of typical ultrasonographic findings, and alcohol consumption of less than 20 g/day in the absence of other causes of liver disease.Results: The mean age of the subjects was 48.6 +/- 11.8 years and 62.4% were female. NAFLD was significantly associated with hypothyroidism (30.2% patients vs. 19.5% control, p<0.001). The prevalence of NAFLD and abnormal liver enzyme levels (ALT > 33/25 IU/L) increased steadily with increasing grades of hypothyroidism (for NAFLD, subclinical: 29.9% and overt: 36.3%; for abnormal ALT, 20.1% and 25.9%, p < 0.001, respectively). Multivariate regression analysis showed that NAFLD was statistically significantly associated with hypothyroidism (odds ratio (OR) 1.38, 95% confidence interval (CI), 1.17-1.62) and the grade of hypothyroidism in a dose-dependent manner (OR 1.36, 95% CI, 1.16-1.61 in subclinical hypothyroidism and OR 1.71, 95% CI, 1.10-2.66 in overt hypothyroidism).Conclusions: Subclinical hypothyroidism, even in the range of upper normal TSH levels, was found to be related to NAFLD in a dose-dependent manner. Hypothyroidism is closely associated with NAFLD independently of known metabolic risk factors, confirming a relevant clinical relationship between these two diseases. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. | en |
dc.language.iso | en | en |
dc.publisher | ELSEVIER | en |
dc.subject | 복합학 | en |
dc.title | Non-alcoholic fatty liver disease across the spectrum of hypothyroidism | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 정고은 | - |
dc.contributor.AlternativeAuthor | 김동희 | - |
dc.contributor.AlternativeAuthor | 김원 | - |
dc.contributor.AlternativeAuthor | 임정윤 | - |
dc.contributor.AlternativeAuthor | 박민정 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.identifier.doi | 10.1016/j.jhep.2012.02.027 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000027897/7 | - |
dc.description.srnd | SEQ:7 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000027897 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A078509 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:9.264 | - |
dc.description.srnd | FILENAME:7.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:yoonjh@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000027897/7 | - |
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