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Efficacy of thymosin α-1 plus peginterferon α-2a combination therapy compared with peginterferon α-2a monotherapy in HBeAg-positive chronic hepatitis B: A prospective, multicenter, randomized, open-label study
DC Field | Value | Language |
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dc.contributor.author | Kim, Bo Hyun | - |
dc.contributor.author | Lee, Youn-Jae | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Jung, Eun Uk | - |
dc.contributor.author | Park, Sung Jae | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.creator | 윤정환 | - |
dc.date.accessioned | 2013-03-29T04:13:09Z | - |
dc.date.available | 2013-03-29T04:13:09Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY Vol.9 No.47, pp. 1048-1055 | - |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81530 | - |
dc.description.abstract | Objective. Thymosin a-1 plus interferon a-2a offers superior efficacy over interferon a-2a alone in patients with chronic
hepatitis B. The aim was to compare the antiviral efficacy of thymosin a-1 plus peginterferon a-2a and peginterferon a-2a alone in HBeAg-positive chronic hepatitis B patients. Materials and methods. HBeAg-positive CHB patients were enrolled in this prospective, randomized, open-label study. Fifty-one patients were assigned to either combination (26 patients; 180 mg of peginterferon a-2a weekly for 48 weeks and 1.6 mg of thymosin a-1 twice a week for the first 12 weeks) or monotherapy (25 patients; 180 mg of peginterferon a-2a weekly for 48 weeks) groups. Results. The rates of the combined response, defined as HBeAg seroconversion, HBV DNA suppression, and normalization of serum ALT, were 4/26 (15.4%) and 3/25 (12.0%) for the combination group and the monotherapy group at the end of treatment (p = 0.725), and 6/26 (23.1%) and 5/25 (20.0%) at the end of follow-up (p = 0.789), respectively. Based on multiple logistic regression analysis, a >2 log10 IU/mL reduction of HBV DNA at week 12 was identified as an independent predictor for combined response (OR, 9.72; 95% CI, 1.33–71.06; p = 0.025) at the end of follow-up. A lower pretreatment HBV DNA level (£7 log10 IU/mL) was another predictor for combined response (OR, 9.64; 95% CI, 1.23–75.32; p = 0.031). No significant differences in adverse events were observed. Conclusions. The short-term addition of thymosin a-1 was not superior to peginterferon a-2a alone in HBeAg-positive CHB patients on the basis of antiviral efficacy. | en |
dc.language.iso | en | en |
dc.publisher | TAYLOR & FRANCIS | en |
dc.subject | 복합학 | en |
dc.subject | chronic hepatitis B | - |
dc.subject | HBV DNA | - |
dc.subject | peginterferon a-2a | - |
dc.subject | thymosin a-1 | - |
dc.title | Efficacy of thymosin α-1 plus peginterferon α-2a combination therapy compared with peginterferon α-2a monotherapy in HBeAg-positive chronic hepatitis B: A prospective, multicenter, randomized, open-label study | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김보현 | - |
dc.contributor.AlternativeAuthor | 이윤재 | - |
dc.contributor.AlternativeAuthor | 김원 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 정은욱 | - |
dc.contributor.AlternativeAuthor | 박성재 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.identifier.doi | 10.3109/00365521.2012.694902 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000027897/6 | - |
dc.description.srnd | SEQ:6 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000027897 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A078509 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:2.019 | - |
dc.description.srnd | FILENAME:5.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:yoonjh@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000027897/6 | - |
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