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Simple Scoring System Predicting Genotypic Resistance During Rescue Therapy for Lamivudine-Resistant Chronic Hepatitis B
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong-Hoon | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Yang, Hyo Joon | - |
dc.contributor.author | Jang, Eun Sun | - |
dc.contributor.author | Kwak, Min-Sun | - |
dc.contributor.author | Hwang, Sang Youn | - |
dc.contributor.author | Yu, Su Jong | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Kim, Chung Yong | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.creator | 윤정환 | - |
dc.date.accessioned | 2013-03-29T04:16:36Z | - |
dc.date.available | 2013-03-29T04:16:36Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | JOURNAL OF GASTROENTEROLOGY Vol.46 No.3, pp. 243-250 | - |
dc.identifier.issn | 0944-1174 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81536 | - |
dc.description.abstract | Goal: In this study, we aimed to devise a simple scoring system predicting the risk of genotypic resistance (GR) to current rescue therapies for patients with lamivudine (LAM)-resistant chronic hepatitis B.Background: LAM and adefovir (ADV) combination therapy should be recommended for an initial rescue therapy against LAM-resistant hepatitis B virus (HBV). However, there still are many LAM-resistant patients being treated with entecavir (ETV) or ADV monotherapy.Study: This retrospective cohort study included consecutive patients treated for LAM-resistant chronic hepatitis B with ETV or ADV monotherapy, or LAM/ADV combination therapy. The cumulative probabilities of GR and virological responses and breakthrough according to clinical variables were analyzed by survival analyses and derived an index for future GR.Results: A total of 224 patients were included (median treatment duration = 117.9 wk). Using risk factors indentified on multivariable analyses, a simple index for future GR (Antiviral Resistance Prediction Index, ARPI) was developed with 3 clinical variables: the rescue therapy regimens (+0, ADV; +1, ETV; +2, LAM/ADV), HBV DNA reduction at 12 weeks (+0, < 3 log(10) copies/mL; +1, >3 log(10) copies/mL), and the initial HBV DNA level (+0, > 10(6) copies/mL; +1, < 10(6) copies/mL). No patient with ARPI >= 2 exhibited GR, whereas 47% of the patients with an ARPI < 2 developed GR by week 144 (P = 0.005).Conclusions: The results of this study suggest that the ARPI is a simple and early index that can be used to determine the risk for subsequent GR during rescue therapy for LAM-resistant chronic hepatitis B. | en |
dc.language.iso | en | en |
dc.publisher | SPRINGER | en |
dc.subject | 복합학 | en |
dc.subject | genotypic resistance | - |
dc.subject | rescue therapy | - |
dc.subject | Antiviral Resistance Prediction Index | - |
dc.title | Simple Scoring System Predicting Genotypic Resistance During Rescue Therapy for Lamivudine-Resistant Chronic Hepatitis B | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이정훈 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 조은주 | - |
dc.contributor.AlternativeAuthor | 양효준 | - |
dc.contributor.AlternativeAuthor | 장은선 | - |
dc.contributor.AlternativeAuthor | 곽민선 | - |
dc.contributor.AlternativeAuthor | 황상윤 | - |
dc.contributor.AlternativeAuthor | 유수종 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 김정용 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.contributor.AlternativeAuthor | 이창훈 | - |
dc.author.alternative | chronic hepatitis B | - |
dc.identifier.doi | 10.1097/MCG.0b013e318225f559 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000027897/12 | - |
dc.description.srnd | SEQ:12 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000027897 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A078509 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:4.16 | - |
dc.description.srnd | FILENAME:12.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:yoonjh@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000027897/12 | - |
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