뇌 해마의 손상이 전간발작에 미치는 영향

Abstract

Cats in which the hippocampus was bilaterally ablated by suction through overlying neocortex (hippocampus operated group) and cats in which only the portion of neocortex over the hippocampus was opened (operated control group) were prepared and their course of experimentally provocated epilepsy by INAH injection was observed compared with that of normal control group (cats without operation). The hippocampus operated group showed: 1) a longer interval between INAH injection and lst seizure. 2) a longer interval between 1st and 2 nd seizure. 3) less frequent seizures in the course. 4) more favorable prognosis than the other groups. Thus it was the author's impression that the hippocampus operated cats seem to have stronger resistance than other cats to the experimentally induced epilepsy by INAH injection, and that the hippocampus has some role to facilitate epileptic activity through the hypothalamic activating systrn.