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Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study

Cited 198 time in Web of Science Cited 205 time in Scopus
Authors
Park, Sang Min; Lim, Min Kyung; Shin, Soon Ae; Yun, Young Ho
Issue Date
2006-11
Publisher
American Society of Clinical Oncology
Citation
JOURNAL OF CLINICAL ONCOLOGY Vol.24 No.31, pp. 5017-5024
Keywords
의약학
Abstract
PurposeAlthough many studies have demonstrated that smoking, alcohol, obesity, and insulin resistance are risk factors for cancer, the role of those factors on cancer survival has been less studied.Patients and MethodsThe study participants were 14,578 men with a first cancer derived from a cohort of 901,979 male government employees and teachers who participated in a national health examination program in 1996. We obtained mortality data for those years from the Korean Statistical Office. We used a standard Poisson regression model to estimate the hazard ratio (HR) for survival in relation to smoking, alcohol, obesity, and insulin resistance before diagnosis.ResultsPoor survival of all cancer combined ( HR, 1.24; 95% CI, 1.16 to 1.33), cancer of the lung ( HR, 1.45; 95% CI, 1.15 to 1.82), and cancer of the liver ( HR, 1.36; 95% CI, 1.21 to 1.53) were significantly associated with smoking. Compared with the nondrinker, heavy drinkers had worse outcomes for head and neck ( HR, 1.85; 95% CI, 1.23 to 2.79) and liver ( HR, 1.25; 95% CI, 1.11 to 1.41) cancer, with dose-dependent relationships. Patients with a fasting serum glucose level above 126 mg/dL had a higher mortality rate for stomach ( HR, 1.52; 95% CI, 1.25 to 1.84) and lung ( HR, 1.48; 95% CI, 1.18 to 1.87) cancer. Higher body mass index was significantly associated with longer survival in head and neck ( HR, 0.54; 95% CI, 0.39 to 0.74) and esophagus ( HR, 0.44; 95% CI, 0.28 to 0.68) cancer.ConclusionPrediagnosis risk factors for cancer development ( smoking, alcohol consumption, obesity, and insulin resistance) had a statistically significant effect on survival among male cancer patients.
ISSN
0732-183X
Language
English
URI
http://hdl.handle.net/10371/81796
DOI
https://doi.org/10.1200/JCO.2006.07.0243
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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