Browse

Expression of UNCL during development of periodontaltissue and response of periodontal ligament fibroblaststo mechanical stress in vivo and in vitro

Cited 8 time in Web of Science Cited 9 time in Scopus
Authors
Kim, Heung-Joong; Choi, Yong Seok; Jeong, Moon-Jin; Kim, Byung-Ock; Lim, Sung-Hoon; Kim, Do Kyung; Kim, Chong Kwan; Park, Joo-Cheol
Issue Date
2007-01
Publisher
SPRINGER
Citation
CELL AND TISSUE RESEARCH Vol.327 No.1, pp. 25-31
Keywords
복합학UNCL,cememtoblast,mechanical stress,Periodontal ligament,fibroblastUNCLPeriodontal ligamentFibroblastMechanical stressCementoblastDifferentiationHumanRat (Sprague-Dawley)
Abstract
Mutations in two genes, uncoordinated (unc) anduncoordinated-like (uncl), lead to a failure of mechanotransductionin Drosophila. UNCL, the human homolog ofunc and uncl, is preferentially expressed in periodontalligament (PDL) fibroblasts compared with gingival fibroblasts.However, the precise role of UNCL in the PDLremains unclear. The aim of the present study has been toexamine whether mechanical stimuli modulate the expressionof UNCL in the human PDL in vivo and in vitro and toexamine the roles of UNCL in the development, regeneration,and repair of the PDL. We have investigated theexpression pattern of UNCL during the development ofperiodontal tissue and the response of PDL fibroblasts tomechanical stress in vivo and in vitro. The expression ofUNCL mRNA and protein increases with PDL fibroblastdifferentiation from the confluent to multilayer stage butslightly decreases on mineralized nodule formation. UNCLhas also been localized in ameloblasts and adjacent cells,differentiating cementoblasts, and osteoblasts of the developingtooth. Strong distinct UNCL expression has furtherbeen observed in the differentiating cementoblasts of thetooth periodontium at the site of tension afterthodontictooth movement. Application of cyclic mechanical stress onPDL fibroblasts increases the expression of UNCL mRNA.These results indicate that UNCL plays important roles inthe development, differentiation, and maintenance ofperiodontal tissues and also suggest a potential role ofUNCL in the mechanotransduction of PDL fibroblasts.
ISSN
0302-766X
Language
English
URI
https://hdl.handle.net/10371/81907
DOI
https://doi.org/10.1007/s00441-006-0304-3
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse