Glycyrrhizin 유도체인 2-Acetoxy 11-Keto 30-Acetoxymethyl Keto Oleanenic Acid와 부신피질 Hormone 분비와의 관계

Abstract

It is a known fact that two molecules of glucuronic acid combined with glycyrrhetinic acid make up the chemical structure of glycyrrhizin, main principle of "Kamcho" or Glycyrrhiza glabra, etc., while the structure of glycyrrhetinic acid, a poly terpene compound, resembles that of phenantherene nucleus of steroid, hormone series. In view of the pharmacological similarity between glycyrrhetinic acid and steroid hormones, the author conducted a series of experiment to .confirrn the pharmacological action of 2-Acetoxy 11- Keto ,d12:13 30-Acetoxymethyl Keto Oleanenic acid, a derivative of glycyrrhizin, which has an even more closer structure to steroid hormones, obtaining the following conclusions: 1. After a successive administration of AMKOA for 7 days, the blood picture of rats revealed an increase of red blood corpuscles and decrease of white blood corpuscles. It also revealed that lymphocytes and eosinophils were decreased, while neutrophils were increased. 2_ In normal rats a successive administration of AM KOA for 3 days resulted in the decrease in the number of circulating eosinophils. No decrease was noticed in adrenalectomized rats. 3. After a successive administration of AMKOA for 7 days sugar content in rat urine appeared to be increased, while nitrogen content indicated no increase of any significance, in contrast with the control group. 4. A successive AMKOA administration seemed to produce under histamine stress an increase in adrenal ascorbic acid content and in adrenal cholesterol content, compared with the control groups. 5. A successive administration of AMKOA for 7 days resulted in an increase of potassium content in rat urine and a decrease of sodium content. 6. A 7 day administration of AMKOA was followed by a slight decrease in 17-Ketosteroid content of rat urine, with no significance recognizable In itself. 7. A 7 day administration of AMKOA produced no difference in hypotensivity of the adrenalectomized rats under histamine stress from the control group, In the group of adrenalectomized rats previously treated with cortisone and DCA an evident inhibition of hypotension was observed. 8. AMKOA had an inhibitory effect upon liver corti· coid metabolism in isolated livers, by paper chromatography.