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Signal Transduction by Cell Adhesion Receptors, Integrins

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Authors
Lee, Jung Weon
Issue Date
2003-03
Publisher
한국분자세포생물학회
Citation
분자세포생물학회뉴스 Vol.15 No.1, pp. 26-36
Keywords
자연과학
Abstract
Interactions of cells with basement
membranes and the extracellular matrices
are crucial for various biological
processes, including the maintenance
of tissue integrity, embryogenesis,
wound healing, and the metastasis
of tumor cells. These processes
involve cell adhesion and migration.
Adhesive and migratory events
require certain biochemical entities,
formation of multiprotein complex
between these entities, and their functional
communication one another.
Cell adhesion is mediated through
cell adhesion receptors or transmembrane
glycoproteins binding to
extracellular matrix (ECM) or counterreceptors
on neighbor cells. Cell
adhesion receptor families include
cadherins, selectins, syndecans, and
the immunoglobulin superfamily of
cell adhesion molecules (IgCAMs).
In this review, integrin-mediated cellular
processes such as cell proliferation
and apoptosis and their molecular
basis will be discussed based
on recent observations, although other cell adhesion receptors can play
important roles or be involved in the
processes and recent outstanding
reviews are also available
Language
Korean
URI
https://hdl.handle.net/10371/82041
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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