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The extracellular loop 2 of TM4SF5 inhibits integrin alpha 2 on hepatocytes under collagen type I environment

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dc.contributor.authorLee, Sin-Ae-
dc.contributor.authorKim, Young Mee-
dc.contributor.authorKwak, Tae Kyoung-
dc.contributor.authorKim, Hyeon Jung-
dc.contributor.authorKim, Semi-
dc.contributor.authorKo, Wonil-
dc.contributor.authorKim, Sung-Hoon-
dc.contributor.authorPark, Ki Hun-
dc.contributor.authorKim, Hyun Jeong-
dc.contributor.authorCho, Moonjae-
dc.contributor.authorLee, Jung Weon-
dc.creator이정원-
dc.date.accessioned2013-04-16T07:53:16Z-
dc.date.available2013-04-16T07:53:16Z-
dc.date.issued2009-11-
dc.identifier.citationCARCINOGENESIS Vol.30 No.11, pp. 1872-1879-
dc.identifier.issn0143-3334-
dc.identifier.urihttps://hdl.handle.net/10371/82057-
dc.description.abstractFour-transmembrane L6 family member 5 (TM4SF5) and its homolog L6, a tumor antigen, form a four-transmembrane L6 family. TM4SF5 expression causes uncontrolled cell proliferation and angiogenesis. Although other genuine transmembrane 4 superfamily (TM4SF) members co-operate with integrins for cell migration, roles of TM4SF5 in the cellular spreading and migration are unknown. Using hepatocarcinoma cell clones that ectopically express TM4SF5, we found that cross talks via an extracellular interaction between TM4SF5 and integrin alpha 2 in collagen type I environment inhibited integrin alpha 2 functions such as spreading on and migration toward collagen I, which were recovered by suppression of TM4SF5 or structural disturbance of its second extracellular loop using a peptide or mutagenesis. Altogether, the observations suggest that TM4SF5 in hepatocytes negatively regulates integrin alpha 2 function via an interaction between the extracellular loop 2 of TM4SF5 and integrin alpha 2 during cell spreading on and migration through collagen I environment.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.subject복합학en
dc.titleThe extracellular loop 2 of TM4SF5 inhibits integrin alpha 2 on hepatocytes under collagen type I environmenten
dc.typeArticle-
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor김영미-
dc.contributor.AlternativeAuthor곽태경-
dc.contributor.AlternativeAuthor김현중-
dc.contributor.AlternativeAuthor김세미-
dc.contributor.AlternativeAuthor고원일-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor박기훈-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor김세미-
dc.contributor.AlternativeAuthor고원일-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor박기훈-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor조문재-
dc.contributor.AlternativeAuthor이정원-
dc.identifier.doi10.1093/carcin/bgp234-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2009-01/102/0000003910/6-
dc.description.srndSEQ:6-
dc.description.srndPERF_CD:SNU2009-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000003910-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A078142-
dc.description.srndDEPT_CD:375-
dc.description.srndCITE_RATE:4.795-
dc.description.srndFILENAME:54SAL_Carcin.pdf-
dc.description.srndDEPT_NM:약학과-
dc.description.srndEMAIL:jwl@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.rimsid2764-
dc.identifier.srnd2009-01/102/0000003910/6-
dc.type.rimsART-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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