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TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity

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dc.contributor.authorKim, Hyeonjung-
dc.contributor.authorKang, Minkyung-
dc.contributor.authorLee, Sin-Ae-
dc.contributor.authorKwak, Tae Kyoung-
dc.contributor.authorJung, Oisun-
dc.contributor.authorLee, Hyo Jeong-
dc.contributor.authorKim, Sung-Hoon-
dc.contributor.authorLee, Jung Weon-
dc.creator이정원-
dc.date.accessioned2013-04-16T07:53:44Z-
dc.date.available2013-04-16T07:53:44Z-
dc.date.issued2010-08-
dc.identifier.citationBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH Vol.1803 No.8, pp. 975-982-
dc.identifier.issn0167-4889-
dc.identifier.urihttps://hdl.handle.net/10371/82062-
dc.description.abstractTransmembrane 4 L six family member 5 (TM4SF5) causes epithelial–mesenchymal transition (EMT) for
aberrant cell proliferation. However, the effects of TM4SF5 expression on cell cycle are unknown so far. In
this study, using hepatocytes that either ectopically or endogenously express TM4SF5 and human
hepatocarcinoma tissues, the role of TM4SF5 in G1/S phase progression was examined. We found that
TM4SF5 expression accelerated G1/S phase progression with facilitated cyclin D1 and E expression and Rb
phosphorylation. Furthermore, TM4SF5 enhanced trafficking of CDK4 and cyclin D1 into the nucleus and
induced complex formation between them. However, TM4SF5-facilitated G1/S phase progression was
blocked by silencing of p27Kip1 using siRNA or by infection of active RhoA. Pharmacological inhibition of
ROCK accelerated the G1/S phase progression of control TM4SF5-unexpressing cells. Altogether, these
observations suggest that TM4SF5 accelerates G1/S phase progression with facilitated CDK4/cyclin D1 entry
into the nucleus, which might be supported by TM4SF5-mediated actin reorganization through cytosolic
p27Kip1 expression and Rho GTPase activity.
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dc.language.isoenen
dc.publisherELSEVIERen
dc.subject복합학en
dc.subjectCytosolic p27Kip1-
dc.subjectCell cycle-
dc.subjectRhoA-
dc.subjectTetraspan-
dc.subject.otherCancer-
dc.titleTM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activityen
dc.typeArticle-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor강민경-
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor곽태경-
dc.contributor.AlternativeAuthor정외선-
dc.contributor.AlternativeAuthor이효정-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor이정원-
dc.identifier.doi10.1016/j.bbamcr.2010.04.001-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2010-01/102/0000003910/4-
dc.description.srndSEQ:4-
dc.description.srndPERF_CD:SNU2010-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000003910-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A078142-
dc.description.srndDEPT_CD:375-
dc.description.srndCITE_RATE:4.733-
dc.description.srndFILENAME:56KHJ_BBAMCR.pdf-
dc.description.srndDEPT_NM:약학과-
dc.description.srndEMAIL:jwl@snu.ac.kr-
dc.description.srndCONFIRM:Y-
dc.identifier.rimsid2534-
dc.identifier.srnd2010-01/102/0000003910/4-
dc.type.rimsART-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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