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TM4SF5 accelerates G1/S phase progression via cytosolic p27(Kip1) expression and RhoA activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyeonjung | - |
dc.contributor.author | Kang, Minkyung | - |
dc.contributor.author | Lee, Sin-Ae | - |
dc.contributor.author | Kwak, Tae Kyoung | - |
dc.contributor.author | Jung, Oisun | - |
dc.contributor.author | Lee, Hyo Jeong | - |
dc.contributor.author | Kim, Sung-Hoon | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.creator | 이정원 | - |
dc.date.accessioned | 2013-04-16T07:53:44Z | - |
dc.date.available | 2013-04-16T07:53:44Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.citation | Biochimica et Biophysica Acta - Molecular Cell Research, Vol.1803 No.8, pp.975-982 | - |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82062 | - |
dc.description.abstract | Transmembrane 4 L six family member 5 (TM4SF5) causes epithelial mesenchymal transition (EMT) for aberrant cell proliferation. However, the effects of TM4SF5 expression on cell cycle are unknown so far. In this study, using hepatocytes that either ectopically or endogenously express TM4SF5 and human hepatocarcinoma tissues, the role of TM4SF5 in G1/S phase progression was examined. We found that TM4SF5 expression accelerated G1/S phase progression with facilitated cyclin D1 and E expression and Rb phosphorylation. Furthermore, TM4SF5 enhanced trafficking of CDK4 and cyclin D1 into the nucleus and induced complex formation between them. However, TM4SF5-facilitated G1/S phase progression was blocked by silencing of p27(Kip1) using siRNA or by infection of active RhoA. Pharmacological inhibition of ROCK accelerated the G1/S phase progression of control TM4SF5-unexpressing cells. Altogether, these observations suggest that TM4SF5 accelerates G1/S phase progression with facilitated CDK4/cyclin D1 entry into the nucleus, which might be supported by TM4SF5-mediated actin reorganization through cytosolic p27(Kip1) expression and Rho GTPase activity. (c) 2010 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Elsevier BV | - |
dc.subject.other | Cancer | - |
dc.title | TM4SF5 accelerates G1/S phase progression via cytosolic p27(Kip1) expression and RhoA activity | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김현정 | - |
dc.contributor.AlternativeAuthor | 강민경 | - |
dc.contributor.AlternativeAuthor | 이신애 | - |
dc.contributor.AlternativeAuthor | 곽태경 | - |
dc.contributor.AlternativeAuthor | 정외선 | - |
dc.contributor.AlternativeAuthor | 이효정 | - |
dc.contributor.AlternativeAuthor | 김성훈 | - |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.identifier.doi | 10.1016/j.bbamcr.2010.04.001 | - |
dc.citation.journaltitle | Biochimica et Biophysica Acta - Molecular Cell Research | - |
dc.identifier.wosid | 000279570700010 | - |
dc.identifier.scopusid | 2-s2.0-77953708780 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2010-01/102/0000003910/4 | - |
dc.description.srnd | SEQ:4 | - |
dc.description.srnd | PERF_CD:SNU2010-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000003910 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A078142 | - |
dc.description.srnd | DEPT_CD:375 | - |
dc.description.srnd | CITE_RATE:4.733 | - |
dc.description.srnd | FILENAME:56KHJ_BBAMCR.pdf | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:jwl@snu.ac.kr | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 982 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 975 | - |
dc.citation.volume | 1803 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Jung Weon | - |
dc.identifier.srnd | 2010-01/102/0000003910/4 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | CYCLIN D1 EXPRESSION | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | ACTIN ORGANIZATION | - |
dc.subject.keywordPlus | DEPENDENT KINASES | - |
dc.subject.keywordPlus | INTEGRIN ALPHA-2 | - |
dc.subject.keywordPlus | INHIBITOR P27 | - |
dc.subject.keywordPlus | CDK INHIBITOR | - |
dc.subject.keywordPlus | HUMAN CANCER | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordAuthor | Cytosolic p27(Kip1) | - |
dc.subject.keywordAuthor | Cell cycle | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | RhoA | - |
dc.subject.keywordAuthor | Tetraspan | - |
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