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Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis

DC Field Value Language
dc.contributor.authorLee, Sin-Ae-
dc.contributor.authorKim, Tae You-
dc.contributor.authorKwak, Tae Kyoung-
dc.contributor.authorKim, Hyeonjung-
dc.contributor.authorKim, Semi-
dc.contributor.authorLee, Hyo Jeong-
dc.contributor.authorKim, Sung-Hoon-
dc.contributor.authorPark, Ki Hun-
dc.contributor.authorKim, Hyun Jeong-
dc.contributor.authorCho, Moonjae-
dc.contributor.authorLee, Jung Weon-
dc.creator이정원-
dc.dateOverexpression of transmembrane 4 L six family member 5 (TM4SF5), a four-transmembrane L6 family member, causes aberrant cell
proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion, and tumor metastasis remain unknown. Using in vitro
hepatocarcinoma cells that ectopically or endogenously express TM4SF5 and in vivo mouse systems, roles of TM4SF5 in metastatic potentials
were examined. We found that TM4SF5 expression facilitated migration, invadopodia formation, MMP activation, invasion, and eventually
lung metastasis in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects. Altogether, TM4SF5-mediated migration and
invasion suggest that TM4SF5 may be therapeutically targeted to deal with TM4SF5-mediated hepatocellular cancers.		-
dc.date.accessioned2013-04-16T07:53:48Z-
dc.date.available2013-04-16T07:53:48Z-
dc.date.issued2010-09-
dc.identifier.citationJOURNAL OF CELLULAR BIOCHEMISTRY Vol.111 No.1, pp. 59-66-
dc.identifier.issn0730-2312-
dc.identifier.urihttps://hdl.handle.net/10371/82063-
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subject복합학en
dc.subjectInvadopodia-
dc.subjectMigration-
dc.subjectInvasion-
dc.subjectTM4SF5-
dc.subjectMMP-
dc.subjectMetastasis-
dc.titleTransmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasisen
dc.typeArticle-
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor김태유-
dc.contributor.AlternativeAuthor곽태경-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor김세미-
dc.contributor.AlternativeAuthor이효정-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor박기훈-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor조문재-
dc.contributor.AlternativeAuthor이정원-
dc.identifier.doi10.1002/jcb.22662-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2010-01/102/0000003910/3-
dc.description.srndSEQ:3-
dc.description.srndPERF_CD:SNU2010-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000003910-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A078142-
dc.description.srndDEPT_CD:375-
dc.description.srndCITE_RATE:3.122-
dc.description.srndFILENAME:57SAL_JCB.pdf-
dc.description.srndDEPT_NM:약학과-
dc.description.srndEMAIL:jwl@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2010-01/102/0000003910/3-
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