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Proteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression.

DC Field Value Language
dc.contributor.authorKim, Jin Young-
dc.contributor.authorNam, Jae Kook-
dc.contributor.authorLee, Sin-Ae-
dc.contributor.authorLee, Mi-Sook-
dc.contributor.authorCho, Somi K.-
dc.contributor.authorPark, Zee-Yong-
dc.contributor.authorLee, Jung Weon-
dc.contributor.authorCho, Moonjae-
dc.creator이정원-
dc.date.accessioned2013-04-16T07:53:52Z-
dc.date.available2013-04-16T07:53:52Z-
dc.date.issued2011-03-
dc.identifier.citationJOURNAL OF CELLULAR BIOCHEMISTRY Vol.112 No.3, pp. 782-792-
dc.identifier.issn0730-2312-
dc.identifier.urihttps://hdl.handle.net/10371/82064-
dc.description.abstractTransmembrane 4 L six family member 5 (TM4SF5) is highly expressed in hepatocarcinoma and causes epithelial–mesenchymal transition
(EMT) of hepatocytes. We found that TM4SF5-expressing cells showed lower mRNA levels but maintained normal protein levels in certain
gene cases, indicating that TM4SF5 mediates stabilization of proteins. In this study, we explored whether regulation of proteasome activity
and TM4SF5 expression led to EMT. We observed that TM4SF5 expression caused inhibition of proteasome activity and proteasome subunit
expression, causing morphological changes and loss of cell–cell contacts. shRNA against TM4SF5 recovered proteasome expression, with
leading to blockade of proteasome inactivation and EMT. Altogether, TM4SF5 expression appeared to cause loss of cell–cell adhesions via
proteasome suppression and thereby proteasome inhibition, leading to repression of cell–cell adhesion molecules, such as E-cadherin. J. Cell.
Biochem.
en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subject복합학en
dc.subjectEpithelial-Mesenchymal Transition-
dc.subjectProteasome-
dc.subjectTetraspan-
dc.subjectTranscription-
dc.titleProteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression.en
dc.typeArticle-
dc.contributor.AlternativeAuthor김진영-
dc.contributor.AlternativeAuthor남재국-
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor이미숙-
dc.contributor.AlternativeAuthor박지용-
dc.contributor.AlternativeAuthor이정원-
dc.contributor.AlternativeAuthor조문재-
dc.identifier.doi10.1002/jcb.22954-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000003910/4-
dc.description.srndSEQ:4-
dc.description.srndPERF_CD:SNU2011-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000003910-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A078142-
dc.description.srndDEPT_CD:375-
dc.description.srndCITE_RATE:2.868-
dc.description.srndFILENAME:59MC-JWL-JCB.pdf-
dc.description.srndDEPT_NM:약학과-
dc.description.srndEMAIL:jwl@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.rimsid2350-
dc.identifier.srnd2011-01/102/0000003910/4-
dc.type.rimsART-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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