간장 표면을 통하 앤티피린의 출입

Abstract

Transport of antipyrine across the surface layer of liver of a rabbit was observed by analyzing the hepatic venous blood specimens obtained through a polyethylene tubing inserted into the left renal vein and vena cava inferior. Adult male rabbits were divided into 3 groups, In the first group which consisted of 7 rabbits, pieces of filter paper soaked in a solution of 2 gm% antipyrine in isotonic saline were placed on the surface of the liver. The area covered by the fllter paper were averaged 40 cm2• Hepatic venous blocd specimens obtained at 2 minutes, 5 minutes and every 5 minutes thereafter were aJ1alyzed for their cr:ncentrations of antipyrine in pla~ma water. In the course of experiments filter papers were removed and the surface of the liver was washed with normal saline solution in some cases, inducing outward movement of antypyrine. In the second group which consisted of 6 rabbits, part of the liver W2S immersed in a soluticn of Igm%