동종 급 이종 위점막조직의 반복주사에의한 백서 위병변에 관한 실험적 연구

Abstract

An experimental study on gastric lesions in rats induced by repeated injections of homologous and heterologous gastric mucosal suspension with Freund's complete adjuvant is made, as an attempt to produce immunological gastritic changes and clarify the nature and significance of this type of lesion as a morphological viewpoint, concerning to a certain human chronic gastric disorders. Followings are the results: 1. A reliable pathologic alteraton of gastric mucosa is only observed in the group of animals that were injected with rat gastric mucosal suspension with adjuvant. Ten from fifteen animals reveal apparent and significant deere ase in number of parietal cells, slight atrophic mucosa, and increased number of mast cells, aside from enhanced exudative inflammatory reaction in the glandular portion of the gastric mucosa. 2. Even though are present difficulty to correlate decreased parietal cell population with inflammatory reaction, there are some evidences to suggest disappearance of parietal cell being followed by atrophic mucosa, at least in long term group. 3. Mild to moderate increase in number of mast cells is observed, particularly in animals having considerable decrease in population of parietal cells. 4. Aside from the above alterations, are encountered irregularity of epithelia, destruction of gastric glands, hyperplasia of foveolar layer, edema, congestion, active lymphoid follicles with plasmocytic zone, intestinalization, and fibrosis of muscularis mucosae. Squamous eqithelial mucosa is devoid of any recognizable alteration. 5. There are observed mild focal thyroiditis in 2 from 15 animals, having notable decrease in population of parietal cells. 6. Two characteristic systemic changes were observed in groups of animals received either adjuvant alone or with tissue suspensions; the one is non-caseous granuloma formation in the injected site of skin, lungs, liver, kidneys, adrenals and Iymphnodes; the another is marked hyperplasia of reticuloendothelial cells of spleen, lymph nodes, bone marrow, and liver, with enhanced infiltration of plasma cells and lymphocytes. From the above morphologic features, the experimental gastric lesions presently described show many similarities to those of chronic gastritis and/or chronic atrophic gastritis, and it is suggested that an immunological process may be concerned in one of the pathogenic pathway of human chronic atrophic gastritis.