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PlexinA2 mediates osteoblast differentiation via regulation of Runx2.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Ji-Eun | - |
dc.contributor.author | Kim, Hyung Joon | - |
dc.contributor.author | Kim, Woo-Shin | - |
dc.contributor.author | Lee, Zang Hee | - |
dc.contributor.author | Ryoo, Hyun-Mo | - |
dc.contributor.author | Hwang, Soon Jung | - |
dc.contributor.author | Lee, Youngkyun | - |
dc.contributor.author | Kim, Hong-Hee | - |
dc.creator | 이장희 | - |
dc.date.accessioned | 2013-04-22T04:26:04Z | - |
dc.date.available | 2013-04-22T04:26:04Z | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | JOURNAL OF BONE AND MINERAL RESEARCH Vol.27 No.3, pp. 552-562 | - |
dc.identifier.issn | 0884-0431 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82235 | - |
dc.description.abstract | The imbalance between bone-resorbing osteoclasts and bone-forming osteoblasts often leads to bone destructive diseases such as
osteoporosis. In contrast to the development of several antiresorptive agents for osteoporosis therapy, discovery of anabolic drugs has been difficult because of an insufficient understanding of the complex mechanism of bone formation. In a microarray analysis with mouse preosteoblast cells, we found that PlexinA2 (PlxnA2), a molecule previously known to mediate axon guidance in neural development, was upregulated by the osteogenic factor BMP2. PlxnA2-specific siRNA decreased Runx2 expression, osteoblast differentiation, and mineralization. Runx2 overexpression restored osteoblastic differentiation of PlxnA2-knockdown cells. PlxnA2 was associated with both type 1 and 2 BMP receptors, and BMP2 increased the interaction between PlxnA2 and type 1 receptors. PlxnA2 also affected Smad and Akt signaling pathways downstream of BMP2. Taken together, the results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling. Therefore, PlxnA2 may be a useful target for development of bone anabolic therapeutics. | - |
dc.language.iso | en | en |
dc.publisher | American Society for Bone and Mineral Research | en |
dc.subject | 의약학 | en |
dc.subject | AXON GUIDANCE MOLECULE | - |
dc.subject | PLEXINA2 | - |
dc.subject | OSTEOBLAST DIFFERENTIATION | - |
dc.subject | RUNX2 | - |
dc.subject | BMP SIGNALING | - |
dc.title | PlexinA2 mediates osteoblast differentiation via regulation of Runx2. | en |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jbmr.1471 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000026258/3 | - |
dc.description.srnd | SEQ:3 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000026258 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A076310 | - |
dc.description.srnd | DEPT_CD:861 | - |
dc.description.srnd | CITE_RATE:6.373 | - |
dc.description.srnd | FILENAME:JBMR-PlexinA2.pdf | - |
dc.description.srnd | DEPT_NM:치의학과 | - |
dc.description.srnd | EMAIL:zang1959@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000026258/3 | - |
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