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Novel extraneural role of neurite outgrowth inhibitor A: modulation of osteoclastogenesis via positive feedback regulation of nuclear factor of activated T cell cytoplasmic 1.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Youngkyun | - |
dc.contributor.author | Kim, Hyung Joon | - |
dc.contributor.author | Park, Cheol Kyu | - |
dc.contributor.author | Kim, Woo-Shin | - |
dc.contributor.author | Lee, Zang Hee | - |
dc.contributor.author | Kim, Hong-Hee | - |
dc.creator | 이장희 | - |
dc.date.accessioned | 2013-04-22T04:26:12Z | - |
dc.date.available | 2013-04-22T04:26:12Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | JOURNAL OF BONE AND MINERAL RESEARCH Vol.27 No.5, pp. 1043-1054 | - |
dc.identifier.issn | 0884-0431 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82237 | - |
dc.description.abstract | Osteoclasts are bone-resorbing cells differentiated from macrophage/monocyte lineage precursors upon receptor activator of NF-kB
ligand (RANKL) stimulation. In a proteomic approach to identify proteins involved in osteoclastogenesis, we observed a dramatic increase in the expression of neurite outgrowth inhibitor A (Nogo-A) upon RANKL stimulation of mouse bone marrow macrophages (BMMs) in a nuclear factor of activated T cell cytoplasmic 1 (NFATc1)-dependent manner. The knockdown of Nogo-A in BMMs significantly reduced RANKL-dependent osteoclast differentiation accompanied by diminished NFATc1 induction, suggesting that a positive feedback mechanism is involved. Conversely, Nogo-A overexpression in BMMs as well as in RAW264.7 macrophages greatly augmented osteoclastogenesis, with concomitant increase in the NFATc1 induction. Both the mitogen-activated protein kinase (MAPK) pathway and calcium oscillation, which are central to RANKL-dependent NFATc1 activation and induction, were enhanced by Nogo-A. Finally, Nogo-A knockdown in mouse calvariae prevented interleukin 1 (IL-1)-induced bone loss. These findings not only reveal an unprecedented extraneural role of Nogo-A in osteoclastogenesis but also suggest a novel drug target against bone-lytic diseases. | - |
dc.language.iso | en | en |
dc.publisher | American Society for Bone and Mineral Research | en |
dc.subject | 의약학 | en |
dc.subject | NOGO-A | - |
dc.subject | OSTEOCLAST | - |
dc.subject | NFATc1 | - |
dc.subject | CALCIUM | - |
dc.subject | MAPK | - |
dc.title | Novel extraneural role of neurite outgrowth inhibitor A: modulation of osteoclastogenesis via positive feedback regulation of nuclear factor of activated T cell cytoplasmic 1. | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이영균 | - |
dc.contributor.AlternativeAuthor | 김형준 | - |
dc.contributor.AlternativeAuthor | 박철규 | - |
dc.contributor.AlternativeAuthor | 김우신 | - |
dc.contributor.AlternativeAuthor | 이장희 | - |
dc.contributor.AlternativeAuthor | 김홍희 | - |
dc.identifier.doi | 10.1002/jbmr.1561 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000026258/2 | - |
dc.description.srnd | SEQ:2 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000026258 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A076310 | - |
dc.description.srnd | DEPT_CD:861 | - |
dc.description.srnd | CITE_RATE:6.373 | - |
dc.description.srnd | FILENAME:JBMR-Nogo.pdf | - |
dc.description.srnd | DEPT_NM:치의학과 | - |
dc.description.srnd | EMAIL:zang1959@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000026258/2 | - |
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