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Novel extraneural role of neurite outgrowth inhibitor A: modulation of osteoclastogenesis via positive feedback regulation of nuclear factor of activated T cell cytoplasmic 1.

DC Field Value Language
dc.contributor.authorLee, Youngkyun-
dc.contributor.authorKim, Hyung Joon-
dc.contributor.authorPark, Cheol Kyu-
dc.contributor.authorKim, Woo-Shin-
dc.contributor.authorLee, Zang Hee-
dc.contributor.authorKim, Hong-Hee-
dc.creator이장희-
dc.date.accessioned2013-04-22T04:26:12Z-
dc.date.available2013-04-22T04:26:12Z-
dc.date.issued2012-05-
dc.identifier.citationJOURNAL OF BONE AND MINERAL RESEARCH Vol.27 No.5, pp. 1043-1054-
dc.identifier.issn0884-0431-
dc.identifier.urihttps://hdl.handle.net/10371/82237-
dc.description.abstractOsteoclasts are bone-resorbing cells differentiated from macrophage/monocyte lineage precursors upon receptor activator of NF-kB
ligand (RANKL) stimulation. In a proteomic approach to identify proteins involved in osteoclastogenesis, we observed a dramatic increase
in the expression of neurite outgrowth inhibitor A (Nogo-A) upon RANKL stimulation of mouse bone marrow macrophages (BMMs) in a
nuclear factor of activated T cell cytoplasmic 1 (NFATc1)-dependent manner. The knockdown of Nogo-A in BMMs significantly reduced
RANKL-dependent osteoclast differentiation accompanied by diminished NFATc1 induction, suggesting that a positive feedback
mechanism is involved. Conversely, Nogo-A overexpression in BMMs as well as in RAW264.7 macrophages greatly augmented
osteoclastogenesis, with concomitant increase in the NFATc1 induction. Both the mitogen-activated protein kinase (MAPK) pathway
and calcium oscillation, which are central to RANKL-dependent NFATc1 activation and induction, were enhanced by Nogo-A. Finally,
Nogo-A knockdown in mouse calvariae prevented interleukin 1 (IL-1)-induced bone loss. These findings not only reveal an
unprecedented extraneural role of Nogo-A in osteoclastogenesis but also suggest a novel drug target against bone-lytic diseases.
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dc.language.isoenen
dc.publisherAmerican Society for Bone and Mineral Researchen
dc.subject의약학en
dc.subjectNOGO-A-
dc.subjectOSTEOCLAST-
dc.subjectNFATc1-
dc.subjectCALCIUM-
dc.subjectMAPK-
dc.titleNovel extraneural role of neurite outgrowth inhibitor A: modulation of osteoclastogenesis via positive feedback regulation of nuclear factor of activated T cell cytoplasmic 1.en
dc.typeArticle-
dc.contributor.AlternativeAuthor이영균-
dc.contributor.AlternativeAuthor김형준-
dc.contributor.AlternativeAuthor박철규-
dc.contributor.AlternativeAuthor김우신-
dc.contributor.AlternativeAuthor이장희-
dc.contributor.AlternativeAuthor김홍희-
dc.identifier.doi10.1002/jbmr.1561-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000026258/2-
dc.description.srndSEQ:2-
dc.description.srndPERF_CD:SNU2012-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000026258-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A076310-
dc.description.srndDEPT_CD:861-
dc.description.srndCITE_RATE:6.373-
dc.description.srndFILENAME:JBMR-Nogo.pdf-
dc.description.srndDEPT_NM:치의학과-
dc.description.srndEMAIL:zang1959@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2012-01/102/0000026258/2-
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