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흰쥐 적혈구세포막에 Aenosine Triphosphatase에 미치는 Diphenyhydantion의 영향 : The Effects of Diphenylhydantoin on Adenosine Triphosphatase Activity in Rat Erythrocyte Membranes
DC Field | Value | Language |
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dc.contributor.author | 이정윤 | - |
dc.date.accessioned | 2009-08-31T15:37:22Z | - |
dc.date.available | 2009-08-31T15:37:22Z | - |
dc.date.issued | 1970-12-01 | - |
dc.identifier.citation | Seoul J Med, Vol.11 No.4, pp. 11-18 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8231 | - |
dc.description.abstract | The effects of diphenylhydantoin on ATPase activity
in rat erythrocyte membranes were studied and also influence of K+ on ATPase activity was studied. The ATPase activity of rat erythrocyte membranes has been shown to consist of two components. The first component requires the Mg"! in the absence of Naror K+ (MgH -A'I'Pase) and is not inhibited by ouabain and stimulated by diphenylhydantoin. The second component requires the presence of MgH and also Nar or K+ (Nar -K+ -A'I'Pase). It is inhibited by ouabain and is stimulated by diphenylhydantoin in 10'.'1' Nat concentration and inhibited in high Na! concentration. Potassium ion reverse the Na' -Kr-A'I'Pase which is inhibited by ouabain. Ouabain and diphenylhydantoin show reversed effect to Na+-K+-ATPase activity. It suggests that the therapeutic effect of diphenylhydantoin 0:1 digitalis induced cardiac arrhythmia may be resulted from their effect on ion transport mechanism of ceIl membrane. And the relevance of these findings to the action of ouabain and diphenylhydantoin on membrane transport mechanism is discussed. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 흰쥐 적혈구세포막에 Aenosine Triphosphatase에 미치는 Diphenyhydantion의 영향 | - |
dc.title.alternative | The Effects of Diphenylhydantoin on Adenosine Triphosphatase Activity in Rat Erythrocyte Membranes | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Lee, Jung Yoon | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 18 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 11-18 | - |
dc.citation.startpage | 11 | - |
dc.citation.volume | 11 | - |
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