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Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells

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dc.contributor.authorKim, Chun Sung-
dc.contributor.authorMoon, In-Sung-
dc.contributor.authorPark, Ju-Hyun-
dc.contributor.authorShin, Woo-Cheol-
dc.contributor.authorLee, Sook-Young-
dc.contributor.authorKim, Heung-Joong-
dc.contributor.authorEndou, Hitoshi-
dc.contributor.authorLee, Byung-Kwon-
dc.contributor.authorKim, Do Kyung-
dc.contributor.authorKanai, Yoshikatsu-
dc.contributor.authorPark, Joo-Cheol-
dc.contributor.authorKook, Joong-Ki-
dc.contributor.authorChun, Hong Sung-
dc.date.accessioned2013-04-30T08:58:21Z-
dc.date.available2013-04-30T08:58:21Z-
dc.date.issued2010-07-
dc.identifier.citationBiological and Pharmaceutical Bulletin, Vol.33, No. 7, pp. 1117-1121ko_KR
dc.identifier.issn0918-6158-
dc.identifier.urihttps://hdl.handle.net/10371/82361-
dc.description.abstractThe purpose of this study was to examine the effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), an inhibitor of L-type amino acid transporters, on the cell growth suppression in KB human oral cancer cells and to study the roles of cell cycle regulatory factors in the BCH-induced growth inhibition. The effect of BCH on cell growth suppression and the influence of BCH to cell cycle regulatory factors in KB cell growth inhibition were examined using cell cycle analysis, immunoblotting and immunoprecipitation. The BCH treatment induced cell cycle arrest at G1 phase in KB cells. The expression of cyclin D3 was remarkably decreased by BCH treatment. The BCH inhibited the expression of cyclin-dependent protein kinase 6 (CDK6) in a time-dependent manner. In addition, the expression of CDK inhibitor p27 was increased by BCH treatment in KB cells, but not CDK inhibitors p21 and p15. These results suggest that, in KB cells, the inhibition of LAT1 by BCH causes cell cycle arrest at Cl phase by inhibiting cyclin D3 CDK6 complex whereas increasing expression of a CDK inhibitor p27.ko_KR
dc.language.isoenko_KR
dc.publisherPharmaceutical Society of Japanko_KR
dc.subjectL-type amino acid transporterko_KR
dc.subjectcancer cellko_KR
dc.subject2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acidko_KR
dc.subjectcell cycle regulatory factorko_KR
dc.titleInhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김춘성-
dc.contributor.AlternativeAuthor문인성-
dc.contributor.AlternativeAuthor박주현-
dc.contributor.AlternativeAuthor신우철-
dc.contributor.AlternativeAuthor이숙영-
dc.contributor.AlternativeAuthor김흥중-
dc.contributor.AlternativeAuthor이병권-
dc.contributor.AlternativeAuthor김도경-
dc.contributor.AlternativeAuthor박주철-
dc.contributor.AlternativeAuthor국중기-
dc.contributor.AlternativeAuthor전홍성-
dc.identifier.doi10.1248/bpb.33.1117-
dc.citation.journaltitleBIOLOGICAL & PHARMACEUTICAL BULLETIN-
dc.description.tc1-
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