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Promotion of Osseointegration of Anodized Titanium Implants with a 1 alpha,25-Dihydroxyvitamin D3 Submicron Particle Coating
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Young-Jin | - |
dc.contributor.author | Heo, Seong-Joo | - |
dc.contributor.author | Koak, Jai-Young | - |
dc.contributor.author | Kim, Seong-Kyun | - |
dc.contributor.author | Lee, Joo-Hee | - |
dc.contributor.author | Lee, Shin-Jae | - |
dc.date.accessioned | 2013-05-01T00:18:56Z | - |
dc.date.available | 2013-05-01T00:18:56Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | International Journal of Oral and Maxillofacial Implants, Vol.26, No.6, pp. 1225-1232 | ko_KR |
dc.identifier.issn | 0882-2786 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22167427 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82365 | - |
dc.description.abstract | Purpose: A biochemical approach to implant surface modification may offer an alternative to physicochemical and morphologic methods for obtaining desirable bone-implant interfaces. The objective of this study was to investigate the bone tissue response to anodized titanium implant surfaces coated with a poly(D, L-lactide-co-glycolide) (PLGA) solution mixed with 1 alpha,25-diydroxyvitamin D3 (1 alpha, 25-(OH)(2)D3) via an electrospray technique. Materials and Methods: Threaded implants were manufactured and anodized under 300 V at 660 Hz for 3 minutes (control group). Half of the implants were then coated with 0.15 mL of the PLGA/1 alpha,25-(OH)(2)D3 solution (5 mu g/implant) via electrospray (experimental group). Surface topography was evaluated using field-emission scanning electron microscopy and optical interferometry. Forty-eight implants (12 implants per group per healing period) were surgically placed in random sites in the tibiae of 12 New Zealand white rabbits. After 4 and 12 weeks of healing, undecalcified ground sections were subjected to histologic and histomorphometric analyses. Results: At week 4, the mean bone-to-implant contact ratio (BIC%) over the entire length of the implant in the experimental group was 37.08% +/- 10.18%, versus 28.01% +/- 8.70% in the control group. The mean BIC% value in the first four consecutive threads of the experimental group was 48.64% +/- 15.92%, compared to 36.11% +/- 13.49% in the control group (P < .05). At week 12, the mean overall BIC% values were 39.10% +/- 7.68% in the experimental group and 29.53% +/- 9.49% in the control group. The mean BIC% value in the first four consecutive threads of the experimental group was 51.80% +/- 16.41%, versus 37.35% +/- 11.77% in the control group (P < .05). Conclusion: The current study demonstrated that the PLGA/1 alpha, 25-(OH)(2)D3 solution coating resulted in submicron-sized particles, which may stimulate bone formation adjacent to the surface of implants inserted into bone. Int J Oral Maxillofac Implants 2011;26:1225-1232 | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Quintessence Publishing | ko_KR |
dc.subject | 1 alpha,25-dihydroxyvitamin D3 | ko_KR |
dc.subject | poly(D,L-lactide-co-glycolide) | ko_KR |
dc.subject | anodized titanium implant | ko_KR |
dc.subject | histomorphometry | ko_KR |
dc.title | Promotion of Osseointegration of Anodized Titanium Implants with a 1 alpha,25-Dihydroxyvitamin D3 Submicron Particle Coating | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 조영진 | - |
dc.contributor.AlternativeAuthor | 허성주 | - |
dc.contributor.AlternativeAuthor | 곽재영 | - |
dc.contributor.AlternativeAuthor | 김성균 | - |
dc.contributor.AlternativeAuthor | 이주희 | - |
dc.contributor.AlternativeAuthor | 이신재 | - |
dc.citation.journaltitle | INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS | - |
dc.description.tc | 0 | - |
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